Results 81 to 90 of about 2,377,300 (402)

Circulating tumor DNA (ctDNA) trajectories predict survival in trifluridine/tipiracil‐treated metastatic colorectal cancer patients

Molecular Oncology, EarlyView.
The authors applied joint/mixed models that predict mortality of trifluridine/tipiracil‐treated metastatic colorectal cancer patients based on circulating tumor DNA (ctDNA) trajectories. Patients at high risk of death could be spared aggressive therapy with the prospect of a higher quality of life in their remaining lifetime, whereas patients with a ...
Matthias Unseld, Stefan Kühberger, Ricarda Graf, Christine Beichler, Markus Braun, Nadia Dandachi, Ellen Heitzer, Gerald W. Prager   +7 more
wiley   +1 more source

Single-chamber pacemakers: with or without leads? Cost-effectiveness and cost-utility analyses

Annals of Medicine
Introduction The evolution in pacemaker technologies has led to improvements in size, weight, functionality, and durability, even as the battery and electrode-based structural configuration has remained essentially the same.Objective To compare the cost ...
José Ramón Lago-Quinteiro, Francisco Reyes-Santias, Manel Antelo, Vicent Caballer-Tarazona, José Luis Martinez-Sande, Javier Garcia-Seara, Moisés Rodriguez-Manero, Jose Ramon Gonzalez-Juanatey   +7 more
doaj   +1 more source

Cost-utility analysis of the fixed-dose combination of dolutegravir/abacavir/lamivudine as initial treatment of HIV+ patients in Spain [PDF]

Farmacia Hospitalaria, 2017
Objective: Fixed-dose combinations of antiretroviral drugs have meant an important step forward in simplifying treatment and improving compliance and has led to an increased effectiveness of therapy, a viral load decrease and improving the quality of ...
Santiago Moreno Guillen, Juan Emilio Losa García, Juan Berenguer Berenguer, José Manuel Martínez Sesmero, Santiago Cenoz Gomis, Ruth Graefenhain, David Lopez Sanchez-Cambronero, Francisco Javier Parrondo Garcia   +7 more
doaj   +1 more source

Health economics and health preference concepts to orthopedics practitioners [PDF]

, 2014
The aim of this study was to describe concepts of health economics in order to update and provide the orthopedic practitioner decision making parameters based on preferences.
Abla, Luiz Eduardo Felipe, Araújo, Carlos Delano Mundim, Ferreira, Lydia Masako, Hochman, Bernardo, Novo, Neil Ferreira, Veiga, Daniela Francescato   +5 more
core   +1 more source

A cost-utility analysis of psychoanalysis versus psychoanalytic psychotherapy [PDF]

International Journal of Technology Assessment in Health Care, 2010
Objectives:Despite the considerable and growing body of research about the clinical effectiveness of long-term psychoanalytic treatment, relatively little attention has been paid to economic evaluations, particularly with reference to the broader range of societal effects. In this cost-utility study, we examined the incremental cost-effectiveness ratio
Berghout, C.C., Zevalkink, D.J., Hakkaart-van Roijen, L.   +2 more
openaire   +6 more sources

Elucidating prognostic significance of purine metabolism in colorectal cancer through integrating data from transcriptomic, immunohistochemical, and single‐cell RNA sequencing analysis

Molecular Oncology, EarlyView.
Low expression of five purine metabolism‐related genes (ADSL, APRT, ADCY3, NME3, NME6) was correlated with poor survival in colorectal cancer. Immunohistochemistry analysis showed that low NME3 (early stage) and low ADSL/NME6 (late stage) levels were associated with high risk.
Sungyeon Kim, Myunghee Kang, Soyeon Jeong, Jisup Kim, Kyoung Oh Kim, Won‐Suk Lee, Jeong‐Heum Baek, Jung Ho Kim, Seungyoon Nam   +8 more
wiley   +1 more source

Surveillance of cirrhosis for hepatocellular carcinoma: a cost–utility analysis [PDF]

British Journal of Cancer, 2008
Using a decision-analytic model, we evaluated the effectiveness and cost-effectiveness of surveillance for hepatocellular carcinoma (HCC) in individuals with cirrhosis. Separate cohorts with cirrhosis due to alcoholic liver disease, hepatitis B and hepatitis C were simulated.
Thompson Coon, J, Rogers, G, Hewson, P, Wright, D, Anderson, R, Jackson, S, Ryder, S, Cramp, M, Stein, K   +8 more
openaire   +5 more sources

Cost Utility Analysis of Lumbar Interlaminar Epidural Injections in the Treatment of Lumbar Disc Herniation, Central Spinal Stenosis, and Axial or Discogenic Low Back Pain.

Pain Physician, 2017
BACKGROUND Cost utility or cost effective analysis continues to take center stage in the United States for defining and measuring the value of treatments in interventional pain management.
L. Manchikanti, V. Pampati, Ramsin M. Benyamin, J. Hirsch   +3 more
semanticscholar   +1 more source

Highly multiplexed digital PCR assay for simultaneous quantification of variant allele frequencies and copy number alterations of KRAS and GNAS in pancreatic cancer precursors

Molecular Oncology, EarlyView.
Combining melting curve analysis enhances the multiplexing capability of digital PCR. Here, we developed a 14‐plex assay to simultaneously measure single nucleotide mutations and amplifications of KRAS and GNAS, which are common driver genes in pancreatic cancer precursors. This assay accurately quantified variant allele frequencies in clinical samples
Junko Tanaka, Tatsuo Nakagawa, Yusuke Ono, Yoshio Kamura, Takeshi Ishida, Hidemasa Kawabata, Kenji Takahashi, Hiroki Sato, Andrew S. Liss, Yusuke Mizukami, Takahide Yokoi   +10 more
wiley   +1 more source

Trastuzumab beyond progression: a cost-utility analysis [PDF]

, 2017
Background: The continuation of trastuzumab beyond progression in combination with capecitabine as secondary chemotherapy for HER2-positive metastatic breast cancer (MBC) prolongs progression-free survival without a substantial increase in toxicity ...
Brauchli, P., Dedes, K. J., Matter-Walstra, K. W., Pestalozzi, B. C., Schwenkglenks, M., Szucs, T. D.   +5 more
core