Results 41 to 50 of about 26,464,921 (304)

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Relational cost analysis [PDF]

ACM SIGPLAN Notices, 2017
Establishing quantitative bounds on the execution cost of programs is essential in many areas of computer science such as complexity analysis, compiler optimizations, security and privacy. Techniques based on program analysis, type systems and abstract interpretation are well-studied, but methods for analyzing how the execution costs of
Ҫiҫek, E., Barthe, G., Gaboardi, M., Garg, D., Hoffmann, J.   +4 more
openaire   +2 more sources

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

FEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace, Alyssa Borges, Charles Arnaud, Tove Karlsson, Nina K. Bröker, Stefanie Barbirz, Marta Bally   +6 more
wiley   +1 more source

Cost Analysis of Inpatient Heart Failure Treatment in Jogja Hospital Based On INA-CBG's Tariffs In 2023

JPSCR: Journal of Pharmaceutical Science and Clinical Research
Heart failure is a catastrophic disease that requires long-term care, resulting in high costs. This study is the first to evaluate the INA-CBG's tariff based on the Minister of Health Regulation Number 3 of 2023 for treating inpatient heart failure. This
Ingenida Hadning, Ahadijatul Kubra
doaj   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Watch-Antibiotic: Teicoplanin: Usage Practices in Various Departments of a Tertiary Care Hospital, Coimbatore, Western Tamil Nadu

National Board of Examinations Journal of Medical Sciences
Background: Watch - antibiotics have high potential to develop resistance. Teicoplanin is one of the antibiotics given under Watch classification in Access, Watch and Reserve (AWaRe), 2023 classification.
M S Umamageswari, G R Gayathri, S Jeevithan, T P Kalaniti, A Vijaya Kumar, M Mohanapriya, B Bharath Kumar, T M Karthikeyan, S Bhuvaneshwari, A T Sathiya Vinotha   +9 more
doaj   +1 more source

A cost analysis of medicine donation programs to Tanzania’s neglected tropical diseases control program [PDF]

, 2019
Masters of Public Health - see Magister Public HealthOverreliance on donor supported health programs has crippled many African countries and there is inadequate long-term planning on the future sustainability of health systems.
Rassa, Adam Omary
core  

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Reliability and Performance Optimization of Multi-Subsystem Systems Using Copula-Based Repair

Axioms
This paper proposes a system made up of four subsystems connected in sequence. The first and third subsystems each have one unit, the second has two, and the fourth has three. Every subsystem operates in parallel and is governed by the K-Out-of-n:G rule.
Elsayed E. Elshoubary, Taha Radwan, Rasha Abd El-Wahab Attwa   +2 more
doaj   +1 more source