Results 81 to 90 of about 6,693,990 (363)

A large‐scale retrospective study in metastatic breast cancer patients using circulating tumour DNA and machine learning to predict treatment outcome and progression‐free survival

Molecular Oncology, EarlyView.
There is an unmet need in metastatic breast cancer patients to monitor therapy response in real time. In this study, we show how a noninvasive and affordable strategy based on sequencing of plasma samples with longitudinal tracking of tumour fraction paired with a statistical model provides valuable information on treatment response in advance of the ...
Emma J. Beddowes, Mario Ortega Duran, Solon Karapanagiotis, Alistair Martin, Meiling Gao, Riccardo Masina, Ramona Woitek, James Tanner, Fleur Tippin, Justine Kane, Jonathan Lay, Anja Brouwer, Stephen‐John Sammut, Suet‐Feung Chin, Davina Gale, Dana W. Y. Tsui, Sarah‐Jane Dawson, Nitzan Rosenfeld, Maurizio Callari, Oscar M. Rueda, Carlos Caldas   +20 more
wiley   +1 more source

North American cost analysis of brand name versus generic drugs for the treatment of glaucoma

ClinicoEconomics and Outcomes Research, 2019
Monali S Malvankar-Mehta,1,2 Lucy Feng,3 Cindy ML Hutnik1,4 1Department of Ophthalmology, Schulich School of Medicine and Dentistry, The University of Western Ontario, London, Ontario N6A 4V2, Canada; 2Department of Epidemiology and Biostatistics ...
Malvankar-Mehta MS, Feng L, Hutnik CML
doaj  

Cost-benefit analysis for commissioning decisions in GEO600 [PDF]

, 2015
Gravitational wave interferometers are complex instruments, requiring years of commissioning to achieve the required sensitivities for the detection of gravitational waves, of order 10^-21 in dimensionless detector strain, in the tens of Hz to several ...
Adams, T., Affeldt, C., Danzmann, K., Degallaix, J., Dooley, K. L., Grote, H., Hild, S., Leong, J. R., Lueck, H., Macleod, D. M., Nuttall, L. K., Prijatelj, M., Schreiber, E., Slutsky, J., Sorazu, B., Strain, K. A., Sutton, P. J., Vahlbruch, H., Was, M., Witte, H.   +19 more
core   +4 more sources

Chemoresistome mapping in individual breast cancer patients unravels diversity in dynamic transcriptional adaptation

Molecular Oncology, EarlyView.
This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the
Maya Dadiani, Gilgi Friedlander, Gili Perry, Nora Balint‐Lahat, Shlomit Gilad, Dana Morzaev‐Sulzbach, Anjana Shenoy, Noa Bossel Ben‐Moshe, Anya Pavlovsky, Rinat Bernstein‐Molho, Eytan Domany, Iris Barshack, Tamar Geiger, Bella Kaufman, Einav Nili Gal‐Yam   +14 more
wiley   +1 more source

Setting priorities in the health care sector – the case of oral anticoagulants in nonvalvular atrial fibrillation in Denmark

ClinicoEconomics and Outcomes Research, 2017
Peter Bo Poulsen,1 Søren Paaske Johnsen,2 Morten Lock Hansen,3 Axel Brandes,4 Steen Husted,5,† Louise Harboe,6 Lars Dybro7 1Pfizer Denmark ApS, Ballerup, 2Department of Clinical Epidemiology, Aarhus University Hospital, 3Department of ...
Poulsen PB, Johnsen SP, Hansen ML, Brandes A, Husted S, Harboe L, Dybro L   +6 more
doaj  

A Systematic Review of Sources of Outcomes and Cost Data Utilized in Economic Evaluation Research Conducted in the Gulf Cooperation Council

Risk Management and Healthcare Policy, 2021
Shiekha S AlAujan, Saja H Almazrou, Sinaa A Al-Aqeel Clinical Pharmacy Department, College of Pharmacy, King Saud University, Riyadh, Saudi ArabiaCorrespondence: Shiekha S AlAujanClinical Pharmacy Department, College of Pharmacy, King Saud University ...
AlAujan SS, Almazrou SH, Al-Aqeel SA
doaj  

Using cost effectiveness analysis; a beginners guide [PDF]

, 2006
Objective ‐ This report seeks to describe the key elements of cost effectiveness analysis (CEA) and to demonstrate how such analysis may be used in the library environment. Methods ‐ The paper uses a step‐by‐step approach to walk the non‐economist
Hulme, C.
core   +1 more source

Tonic signaling of the B‐cell antigen‐specific receptor is a common functional hallmark in chronic lymphocytic leukemia cell phosphoproteomes at early disease stages

Molecular Oncology, EarlyView.
B‐cell chronic lymphocytic leukemia (B‐CLL) and monoclonal B‐cell lymphocytosis (MBL) show altered proteomes and phosphoproteomes, analyzed using mass spectrometry, protein microarrays, and western blotting. Identifying 2970 proteins and 316 phosphoproteins, including 55 novel phosphopeptides, we reveal BCR and NF‐kβ/STAT3 signaling in disease ...
Paula Díez, Pablo Juanes‐Velasco, Marina L. García‐Vaquero, Conrad Droste, Alicia Landeira‐Viñuela, Miguel Alcoceba, Helena Fidalgo‐Gómez, Sara Misiego‐Herrero, Almudena Navarro‐Bailón, Mónica Baile, José M. Bastida, Jose Manuel Sanchez‐Santos, Rafael Góngora, Julia Almeida, Marcos Gonzalez‐Diaz, Alberto Orfao, Javier De Las Rivas, Manuel Fuentes   +17 more
wiley   +1 more source

Comparative Analysis of Transaction Costs, Revenues, and Welfare of Plasma and Self-supporting Oil Palm Farmers in Tulang Bawang Regency [PDF]

, 2018
Transaction costs arise as a result of uncertainty in the transaction environment. Vertical integration of farmers in an institution will reduce uncertainty and will reduce transaction costs.
Ismono, R. H. (R), Lestari, D. A. (Dyah), Prasmatiwi, F. E. (Fembriarti)   +2 more
core  

Detecting homologous recombination deficiency for breast cancer through integrative analysis of genomic data

Molecular Oncology, EarlyView.
This study develops a semi‐supervised classifier integrating multi‐genomic data (1404 training/5893 validation samples) to improve homologous recombination deficiency (HRD) detection in breast cancer. Our method demonstrates prognostic value and predicts chemotherapy/PARP inhibitor sensitivity in HRD+ tumours.
Rong Zhu, Katherine Eason, Suet‐Feung Chin, Paul A. W. Edwards, Raquel Manzano Garcia, Richard Moulange, Jia Wern Pan, Soo Hwang Teo, Sach Mukherjee, Maurizio Callari, Carlos Caldas, Stephen‐John Sammut, Oscar M. Rueda   +12 more
wiley   +1 more source