Results 71 to 80 of about 26,173,909 (277)
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
EClinicalMedicineSummary: Background: To date, economic analyses of tissue-based next generation sequencing genomic profiling (NGS) for advanced solid tumors have typically required models with assumptions, with little real-world evidence on overall survival (OS ...
Alberto Hernando-Calvo +22 more
doaj +1 more source
Journal of Ocean Engineering and Science, 2019 Risk assessment is a fundamental activity to evaluate the integrity of pipeline systems during their life cycle, which allows pipeline operators to focus attention on integrity management activities in order to prevent and mitigate failure and maintain ...
Bahram Mehrafrooz +2 more
doaj +1 more source
Journal of Eating Disorders, 2020 Background Family-based treatment (FBT) is an efficacious outpatient intervention for young people diagnosed with Anorexia Nervosa (AN). To date, treatment to protocol has relied on standard face-to-face delivery.
A. Hambleton +5 more
doaj +1 more source
FEBS Letters, EarlyView.We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace +6 more
wiley +1 more source
Model-Theoretic Investigations into Consequence Operation (Cn) in Quantum Logics: An Algebraic Approach. [PDF]
, 2006 In this paper, we present the fundamentals of the so-called algebraic approach to propositional quantum logics. We define the set of formulae describing quantum reality as a free algebra freely generated by the set of quantum proportional variables.
WILCZEK, Piotr, Piotr Wilczek
core +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
The structure of logical consequence : proof-theoretic conceptions [PDF]
, 2010 The model-theoretic analysis of the concept of logical consequence has come under heavy criticism in the last couple of decades. The present work looks at an alternative approach to logical consequence where the notion of inference takes center stage ...
Hjortland, Ole T.
core +2 more sources