Results 81 to 90 of about 26,173,909 (277)

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Cost-consequence model comparing eltrombopag versus romiplostim for adult patients with chronic immune thrombocytopenia

, 2018
Gabriel Tremblay,1 Mike Dolph,1 Menaka Bhor,2 Qayyim Said,2 Brian Elliott,2 Andrew Briggs3 1Department of Health Economics, Purple Squirrel Economics, New York, NY, USA; 2Department of Health Economics and Outcomes Research, Novartis Pharmaceuticals ...
Said Q, Tremblay G, Briggs A, Bhor M, Elliott B, Dolph M   +5 more
core  

Cost-consequence analysis of influenza vaccination among the staff of a large teaching hospital in Rome, Italy: A pilot study [PDF]

, 2019
Flu vaccination, as well as being effective to prevent seasonal influenza, decreases staff illness and absenteeism and reduces costs resulting from loss of productivity. Despite the effectiveness of flu vaccination, the seasonal coverage among healthcare
Americo Cicchetti, Walter Ricciardi (15986), Andrea Barbara, Filippo Berloco, Andrea Barbara (7866200), Daniele Piacentini (7866206), Andrea Cambieri, Andrea Gentili (3425243), Patrizia Laurenti, Laurenti, Patrizia, Berloco, Filippo, Andrea Tamburrano (7866197), Piacentini, Daniele, Daniele Piacentini, Daniele Ignazio La Milia (7866203), Patrizia Laurenti (7866218), Vittoria Colamesta, Ricciardi, Walter, Andrea Gentili, Cicchetti, Americo, Gentili, Andrea, Sergio Riccardo Mastrodonato (7866212), Barbara, Andrea, Americo Cicchetti (4041329), Filippo Berloco (5508689), Roberta Galluzzi (7866209), Walter Ricciardi, Daniele Ignazio La Milia, Andrea Tamburrano, Andrea Cambieri (7866215), Vittoria Colamesta (4966333), Roberta Galluzzi, Cambieri, Andrea, Sergio Riccardo Mastrodonato   +33 more
core   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Cost-consequence analysis of extended loading dose of anti-VEGF treatment in diabetic macular edema patients

BMC Ophthalmology, 2020
Background The DRCR.net Protocol T clinical trial assessed the comparative efficacy and safety of anti-VEGF treatments including aflibercept, ranibizumab and bevacizumab in diabetic macular edema (DME).
J. M. Ruiz-Moreno, F. de Andrés-Nogales, I. Oyagüez   +2 more
doaj   +1 more source

Cost-effectiveness and cost-benefit analysis of governance and anti-corruption activities [PDF]

, 2014
Cost-effectiveness and cost-benefit analysis methods are currently underutilised in evaluations of governance and anti-corruption reforms in developing countries.
Johnsøn, Jesper
core  

Cost-consequence Analysis of Secukinumab vs Adalimumab in Moderate-to-severe Hidradenitis Suppurativa

Actas Dermo-Sifiliográficas
Background and objective: Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease. Treatment for moderate-to-severe HS includes biologic therapies (adalimumab and secukinumab), resulting in increased disease management costs.
A. Martorell, A. Molina-Leyva, A. Jiménez Morales, C. Blanch   +3 more
doaj   +1 more source

Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy

FEBS Letters, EarlyView.
The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley   +1 more source

Cost-utility analysis: Incremental cost-effectiveness ratio (ICER)—base case.

, 2019
Cost-utility analysis: Incremental cost-effectiveness ratio (ICER)—base case.
Frauke Becker (2836922), Denise Howel (16468), Catherine Haighton (2157001), Martin White (16466), Andrew Bryant (5704967), Terry Aspray (6194804), Luke Vale (3435356), Elaine McColl (533649), Suzanne Moffatt (16467), Sarah Lawson (6194801), Melanie Steer (6194798), Eugene M. G. Milne (2215138)   +11 more
core   +1 more source