Results 71 to 80 of about 9,605,234 (296)

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

open access: yesMolecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou   +4 more
wiley   +1 more source

Task Force on Effective and Cost-Efficient Service Provision [PDF]

open access: yes, 2010
This archived document is maintained by the Oregon State Library as part of the Oregon Documents Depository Program. It is for informational purposes and may not be suitable for legal purposes.Mode of access: Internet from the Oregon Government ...

core  

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

open access: yesMolecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic   +10 more
wiley   +1 more source

Orthopaedic oncology – the challenges ahead

open access: yesFrontiers in Surgery, 2014
Orthopaedic oncology one of the relatively newer sub specialties in orthopaedics has seen rapid strides in recent years. Function preserving alternatives have largely replaced amputation as the means to achieve local control in malignant bone tumors ...
Ajay ePuri
doaj   +1 more source

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

open access: yesMolecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez   +5 more
wiley   +1 more source

Comparative evaluation of various extraction techniques for analysis of Hexaconazole residues in Soils

open access: yesEnvironment Conservation Journal, 2013
The extraction of hexaconazole (fungicide) residues from the soil samples was conducted by noval extraction techniques like ASE along with traditional methods like soxhlet, column and mechanical shaking.
Khushbu Sharma   +3 more
doaj   +1 more source

A cost-effective BCI assisted technology framework for neurorehabilitation

open access: yes, 2018
Brain Computer Interface (BCI) controlled assistive robotic systems have been developed with increasing success with the aim to rehabilitate brain injured patients to increase independence and quality of life.
Azhar, H., Casey, A., Sakel, M.
core  

Cost-Effective Designs for Trials with Discrete-Time Survival Endpoints [PDF]

open access: yes, 2012
In studies on event occurrence, the timing of events may be measured continuously using thin precise units or discretely using time periods. The design of trials with continuous-time survival endpoints has been studied for years, but very little is known
Jozwiak, K.   +3 more
core   +1 more source

Bridging the gap: a genetically validated avian chorioallantoic membrane platform for investigation of spontaneous circulating tumor cells

open access: yesMolecular Oncology, EarlyView.
We established the avian chorioallantoic membrane (CAM) assay as a scalable in vivo model for studying circulating tumor cells (CTCs). Human gastrointestinal tumors spontaneously released genetically validated CTCs that were detected across multiple platforms, demonstrating that the CAM model provides an accessible tool for investigating early cancer ...
Dennis Roth   +17 more
wiley   +1 more source

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