Results 51 to 60 of about 403,179 (312)

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

FEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

Analyzing an efficient mix design for the production of quality asphalt concrete: A means of reducing roads’ maintenance cost

Journal of Sustainable Construction Materials and Technologies
Poor road design is the bedrock for strength deformation and formation of potholes in road pavement systems. The best choice of aggregates for asphalt concrete production contributes significantly to road pavement stability, sustainability, and ...
Akinniyi Akinjide Adelani, Oladipupo Seun Oladejo, Ademilade Olubambi, Bolanle Deborah Ikotun, Abiodun Kilani   +4 more
doaj   +1 more source

Cost Data Modelling and Searching to Support Low Volume, High Complexity, Long Life Defence Systems Development

, 2015
This paper presents a data modelling and a semi-automatic data searching method to support cost estimation in the product development process, particularly for low volume, high complexity and long life products typified by defence products and systems ...
Marsh, Robert, Cheung, Wai Ming, Mileham, Antony, Newnes, Linda, Lanham, John   +4 more
core   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Evaluation of Earned Value Management-Based Cost Estimation via Machine Learning

Buildings
Accurate estimation of construction costs is of foremost importance in construction management processes. Considering the changes and unexpected situations, cost estimations should be revised during the construction process.
Gamze Yalçın, Savaş Bayram, Hatice Çıtakoğlu   +2 more
doaj   +1 more source

Specific costs and gross margins: estimation practices

, 2023
International audienceThis paper presents the extension to the analysis of interval data of a statistical processing chain for the dual estimation of specific cost and gross margin ...
Desbois, Dominique
core  

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source

Empirical Investigation About the Factors Affecting the Cost Estimation in Global Software Development Context

IEEE Access, 2021
Software organization always aims at developing a quality software product using the estimated development resources, effort, and time. Global Software Development (GSD) has emerged as an essential tool to ensure optimal utilization of resources, which ...
Junaid Ali Khan, Saif Ur Rehman Khan, Javed Iqbal, Inayat Ur Rehman   +3 more
doaj   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Cost modelling for manufacturing of aerospace composites [PDF]

, 2011
The application of composites has been increasing dramatically in aerospace structures recently, for example, composites have contributed over 50 percent of the structure mass of large transport airplanes Boeing 787 and Airbus 350XWB.
Ma, Weitao
core