Results 51 to 60 of about 8,181,646 (253)
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Modelling of cost-functions under risk and uncertainty
Acta Universitatis Agriculturae et Silviculturae Mendelianae Brunensis, 2009 In economics, a cost curve is a graph of the costs of production as a function of total quantity produced. In a free market economy, these curves are used by the entities to find the optimal point of production, where they make the highest profits. There
Michaela Beranová, Dana Martinovičová
doaj +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
D2D Spectrum Efficiency Optimization Algorithm for Many-to-One Reusing Scenarios
IEEE AccessIn order to solve the spectrum efficiency optimization problem of device-to-device (D2D) communication in many-to-one reusing mode, the channel allocation and power control problem in the frequency-selective channel environment is investigated.
Hui Dun, Erryang Huan
doaj +1 more source
Formalization of Cost and Utility in Microeconomics
Energies, 2020 Cost and utility modeling of economics agents based on the differential theory is fundamental to the analysis of the microeconomics models. In particular, the first and second-order derivative tests are used to specify the desired properties of the cost ...
Asad Ahmed +3 more
doaj +1 more source
Factors Affecting the Growth of Demand on Carsharing Services Within Smart City
Transport and Telecommunication, 2022 The carsharing services have become the necessary component of the life of smart and sustainable city. They meet the numerous requirements put forward by these cities concepts and make life in urban environment cleaner, more comfortable and convenient ...
Popova Yelena, Fesyuk Alexandra
doaj +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Neural Tract Avoidance Path-Planning Optimization: Robotic Neurosurgery
Applied SciencesBackground: We propose a three-dimensional path-planning method to generate optimized surgical trajectories for steering flexible needles along curved paths while avoiding critical tracts in the context of surgical glioma resection. Methods: Our approach
Juliana Manrique-Cordoba +3 more
doaj +1 more source
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
Modified Cuckoo Search Algorithm for Solving Nonconvex Economic Load Dispatch Problems
Advances in Electrical and Electronic Engineering, 2016 This paper presents the application of modified cuckoo search algorithm (MCSA) for solving economic load dispatch (ELD) problems. The MCSA method is developed to improve the search ability and solution quality of the conventional CSA method. In the MCSA,
Thang Trung Nguyen +3 more
doaj +1 more source