Results 81 to 90 of about 2,221,727 (381)

A large‐scale retrospective study in metastatic breast cancer patients using circulating tumour DNA and machine learning to predict treatment outcome and progression‐free survival

Molecular Oncology, EarlyView.
There is an unmet need in metastatic breast cancer patients to monitor therapy response in real time. In this study, we show how a noninvasive and affordable strategy based on sequencing of plasma samples with longitudinal tracking of tumour fraction paired with a statistical model provides valuable information on treatment response in advance of the ...
Emma J. Beddowes, Mario Ortega Duran, Solon Karapanagiotis, Alistair Martin, Meiling Gao, Riccardo Masina, Ramona Woitek, James Tanner, Fleur Tippin, Justine Kane, Jonathan Lay, Anja Brouwer, Stephen‐John Sammut, Suet‐Feung Chin, Davina Gale, Dana W. Y. Tsui, Sarah‐Jane Dawson, Nitzan Rosenfeld, Maurizio Callari, Oscar M. Rueda, Carlos Caldas   +20 more
wiley   +1 more source

Estimating the economic life of forest machinery using the cumulative cost model and cost minimization model in Iranian Caspian forests

Journal of Forest Science, 2018
This study was conducted in order to estimate the economic life of two models of rubber-tired skidders, namely Timberjack 450C and HSM 904, in Iranian Caspian forests. The total annual costs and average cumulative cost of skidders were calculated by life-
Mohammad HEJAZIAN, Majid LOTFALIAN, Soleiman MOHAMMADI LIMAEI   +2 more
doaj   +1 more source

Ergodic Control of Resource Sharing Networks: Lower Bound on Asymptotic Costs [PDF]

arXiv, 2023
Dynamic capacity allocation control for resource sharing networks (RSN) is studied when the networks are in heavy traffic. The goal is to minimize an ergodic cost with a linear holding cost function. Our main result shows that the optimal cost associated with an associated Brownian control problem provides a lower bound for the asymptotic ergodic cost ...
arxiv  

Cost minimization analysis of line probe assay for detection of multidrug-resistant tuberculosis in Arkhangelsk region of Russian Federation

PLoS ONE, 2019
Background The development of new diagnostic tools allows for faster detection of both tuberculosis (TB) and multidrug-resistant (MDR) TB and should lead to reduced transmission by earlier initiation of anti TB therapy.
E. Bogdanova, A. Mariandyshev, G. Balantcev, P. Eliseev, E. Nikishova, A. Gaida, D. Enarson, A. Detjen, R. Dacombe, P. Phillips, S. Squire, E. Gospodarevskaya, E. Gospodarevskaya   +12 more
semanticscholar   +1 more source

Linear model for fast background subtraction in oligonucleotide microarrays [PDF]

, 2009
One important preprocessing step in the analysis of microarray data is background subtraction. In high-density oligonucleotide arrays this is recognized as a crucial step for the global performance of the data analysis from raw intensities to expression ...
Barkema, Gerard T., Carlon, Enrico, Kroll, K. Myriam   +2 more
core   +4 more sources

Tonic signaling of the B‐cell antigen‐specific receptor is a common functional hallmark in chronic lymphocytic leukemia cell phosphoproteomes at early disease stages

Molecular Oncology, EarlyView.
B‐cell chronic lymphocytic leukemia (B‐CLL) and monoclonal B‐cell lymphocytosis (MBL) show altered proteomes and phosphoproteomes, analyzed using mass spectrometry, protein microarrays, and western blotting. Identifying 2970 proteins and 316 phosphoproteins, including 55 novel phosphopeptides, we reveal BCR and NF‐kβ/STAT3 signaling in disease ...
Paula Díez, Pablo Juanes‐Velasco, Marina L. García‐Vaquero, Conrad Droste, Alicia Landeira‐Viñuela, Miguel Alcoceba, Helena Fidalgo‐Gómez, Sara Misiego‐Herrero, Almudena Navarro‐Bailón, Mónica Baile, José M. Bastida, Jose Manuel Sanchez‐Santos, Rafael Góngora, Julia Almeida, Marcos Gonzalez‐Diaz, Alberto Orfao, Javier De Las Rivas, Manuel Fuentes   +17 more
wiley   +1 more source

Cost-minimization analysis of degludec/liraglutide versus glargine/aspart: economic implications of the DUAL VII study outcomes

ClinicoEconomics and Outcomes Research, 2018
Enrico Torre,1 Giacomo Matteo Bruno,2 Sergio Di Matteo,2 Chiara Martinotti,2 Martina Oselin,2 Maria Chiara Valentino,2 Alessio Parodi,3 Luigi Carlo Bottaro,4 Giorgio Lorenzo Colombo5 1Endocrinology, Diabetology and ...
Torre E, Bruno GM, Di Matteo S, Martinotti C, Oselin M, Valentino MC, Parodi A, Bottaro LC, Colombo GL   +8 more
doaj  

Planning routes in road freight minimizing logistical costs and accident risks [PDF]

arXiv, 2022
The Vehicle Routing Problem (VRP) has been widely studied throughout its history as a way of optimizing routes by minimizing distances, and the issue of risk in VRP has been received less attention, which is essential to increase transport safety, to reduce accident costs and to improve delivery reliability.
arxiv  

Cost savings with transcutaneous screening versus total serum bilirubin measurement for newborn jaundice in hospital and community settings: a cost-minimization analysis.

CMAJ Open, 2018
BACKGROUND Leading authorities in North America recommend universal screening via total serum bilirubin (TSB) measurement or transcutaneous bilirubinometry (TcB) for kernicterus prevention.
Stephanie McClean, K. Baerg, J. Smith-Fehr, M. Szafron   +3 more
semanticscholar   +1 more source

Cost Minimization Analysis of Same-Day Long-Acting Reversible Contraception for Adolescents [PDF]

, 2019
Importance: Long-acting reversible contraception (LARC) is considered first-line contraception for adolescents but often requires multiple clinic visits to obtain.
Downs, Stephen M., Tucker Edmonds, Brownsyne, Wilkinson, Tracey A.   +2 more
core   +1 more source