Results 51 to 60 of about 1,566,854 (312)
FEBS Letters, EarlyView.Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil +4 more
wiley +1 more source
Post-Handover Housing Quality Management and Standards in Korea
Buildings, 2023 Housing quality is a subject of dispute worldwide, and these disputes are increasing due to the significant differences in the views of producers and consumers on quality standards.
Junmo Park, Deokseok Seo
doaj +1 more source
Cost-effectiveness of magnetic resonance-guided focused ultrasound surgery for treatment of uterine fibroids [PDF]
, 2007 OBJECTIVE: To estimate the cost-effectiveness of a treatment strategy for symptomatic uterine fibroids, which starts with Magnetic Resonance-guided Focused Ultrasound Surgery (MRgFUS) as compared with current practice comprising uterine artery ...
Cairns, JA +6 more
core +1 more source
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
FEBS Letters, EarlyView.An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley +1 more source
Health economics and health preference concepts to orthopedics practitioners [PDF]
Acta Ortopédica Brasileira, 2014 The aim of this study was to describe concepts of health economics in order to update and provide the orthopedic practitioner decision making parameters based on preferences.
Carlos Delano Mundim Araújo +5 more
doaj +1 more source
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
The economic burden and quality of life of patients with psoriasis treated with biologics in China
Journal of Dermatological Treatment, 2023 Background Although biologics improve the quality of life of psoriasis patients, they also impose a substantial economic burden. There is a lack of research addressing the economic and humanistic impact of biologics in China.
Shuhui Min +4 more
doaj +1 more source
Developing a Framework for Improving the Quality of Cost Estimates [PDF]
, 2008 Cost estimating is a knowledge intensive task, involving a high degree of subjectivity. Consequently, many of the current cost estimating (CE) processes lack formalisation, often resulting in the branding of cost estimating as a “part art, part science”
Lavdas, Evaggelos
core
Molecular Oncology, EarlyView.Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen +11 more
wiley +1 more source