Results 41 to 50 of about 4,452,010 (286)
Gerokomos, 2009 Introducción: Las úlceras por presión (UPP) representan un importante problema de salud en todos los niveles asistenciales, pero un volumen importante de las mismas precisan de cuidados continuados desde la comunidad.
Juan de Con Redondo +1 more
doaj
COMENTARIOS SOBRE EL RÉGIMEN ESPECIAL DEL GRUPO DE ENTIDADES EN EL IMPUESTO SOBRE EL VALOR AÑADIDO (II) [PDF]
Crónica Tributaria, 2018 El autor, en dos partes, comenta el contenido, características y finalidad del denominado «régimen especial del grupo de entidades» (REGE) en el IVA, a partir del estudio de la normativa y doctrina europeas, así como de la legislación y doctrina ...
Domingo Carbajo Vasco
doaj
Cell, 2011 SUMMARY Double-strand breaks (DSBs) in heterochromatic repetitive DNAs pose significant threats to genome integrity, but information about how such lesions are processed and repaired is sparse. We observe dramatic expansion and dynamic protrusions of the
I. Chiolo +5 more
semanticscholar +1 more source
Fundamental Biological Features of Spaceflight: Advancing the Field to Enable Deep Space Exploration
Cell, 2020 Research on astronaut health and model organisms have revealed six features of spaceflight biology which guide our current understanding of fundamental molecular changes that occur during space travel.
Ebrahim Afshinnekoo +37 more
semanticscholar +1 more source
FEBS Letters, EarlyView.We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace +6 more
wiley +1 more source
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Agroecosistemas, 2021 La producción bananera, es uno de los sectores económicos más importante del Ecuador, debido al aporte que brinda en materia de tributos y plazas de empleo para miles de familias a lo largo de las provincias donde se produce la fruta; el objetivo de la ...
Chuquirima Espinoza, Samuel Efraín +2 more
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Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
OBSERVATORIO DE COSTES Y FINANCIACIÓN DEL TRANSPORTE URBANO COLECTIVO: UN PROGRAMA DE INVESTIGACIÓN [PDF]
, 2014 El Observatorio de Costes y Financiación del Transporte Urbano Colectivo y sus informes anuales sobre el sector constituyen una excelente plataforma para mejorar el conocimiento de su estructura de costes, posibilitar prácticas de benchmarking a las ...
Sánchez Toledano, Daniel +2 more
core +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source