Results 51 to 60 of about 4,452,010 (286)

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Incremento de costes atribuible a la infección quirúrgica de la apendicectomía y colectomía

, 2003
Objetivo: Determinar los costes mediante la medicion directa, caso a caso, de la infeccion del sitio quirurgico en la apendicectomia y la colectomia. Metodos: Diseno: estudio de casos y controles con base poblacional; los casos fueron todos los pacientes
J. Ríos, Carles Murillo, G. Carrasco, C. Humet   +3 more
semanticscholar   +1 more source

Accounting management of property, plant and equipment under international standards in tourist transport companies

Revista Arbitrada Interdisciplinaria Koinonía, 2020
The objective of this research is to propose an optimal accounting management system for property, plant and equipment for the tourist land transport sector of Azuay. Non-experimental descriptive type.
Daysi Yessenia Ortiz-Jara, Héctor Espinoza-Pillaga, Verónica Paulina Moreno-Narváez   +2 more
doaj   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Impacto da formação profissional contínua nos custos do tratamento das feridas crónicas Impacto de la formación profesional continua en los costes de tratamiento de las heridas crónicas Impact of continuing professional education on treatment costs for chronic wounds

Revista de Enfermagem Referência, 2010
Nos contextos da prestação de cuidados de saúde, os avanços da ciência e da tecnologia rapidamente desactualizam as competências específicas adquiridas nas escolas.
Pedro João Soares Gaspar, Rogério Paulo Pais Costa, João Emanuel Gonçalves Costa, Joseph Maria Monguet Fierro, Jordi Ojeda Rodrigues   +4 more
doaj  

Programación y compromiso. Cómo equilibrar dos objetivos, económico y ambiental, en una promoción de viviendas

Economía Agraria y Recursos Naturales, 2015
En la construcción de edificios entran en conflicto el objetivo económico para el usuario y el objetivo ambiental para la sociedad. La aplicación de la metodología multiobjetivo y programación compromiso puede ser útil para definir la composición óptima ...
Natividad Guadalajara Olmeda, Mª José Ruá Aguilar   +1 more
doaj   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source