Results 31 to 40 of about 1,468,261 (263)
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
Costos y Gestión, 2019 El entrevistado cumple actualmente funciones como Director Ejecutivo de la AHT (Asociación de Hoteles de Turismo de la Rep. Argentina). Así como también en Wyndham Nordelta Tigre Hotel.
Julio Marchione
doaj +2 more sources
FEBS Letters, EarlyView.An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley +1 more source
FEBS Letters, EarlyView.The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson +6 more
wiley +1 more source
FEBS Letters, EarlyView.We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace +6 more
wiley +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Control de gestión para una red de pymes agroturísticas orientadas a la calidad territorial
Costos y Gestión, 2015 Varias pequeñas empresas agrarias, muchas de ellas familiares, se han asociado bajo el programa Cambio Rural INTA (Instituto Nacional de Tecnología Agropecuaria), que encuadrado en el Programa Federal de Apoyo al Desarrollo Rural Sustentable (ProFeDeR),
Regina Durán +5 more
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EFECTOS AMBIENTALES Y SUS COSTOS EN EL TRÁNSITO HACIA LA VIRTUALIDAD ACADÉMICA
Costos y Gestión, 2020 Tendencias globales como la sostenibilidad de las prácticas organizativas, adhesión a estándares internacionales y reducción de residuos se perciben en las exigencias de la sociedad a través de la presión legislativa y la demanda de transparencia ...
Alejandra Narvarte +2 more
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