Results 81 to 90 of about 6,737,738 (307)

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source

LOS DESAFÍOS DE LA EDUCACIÓN SUPERIOR Y SU IMPACTO EN LA CALIDAD DEL SERVICIO EN LAS UNIVERSIDADES PRIVADAS DEL LÍBANO

Costos y Gestión, 2021
En el contexto de la globalización, la privatización y la liberalización, se produjeron cambios importantes en el entorno educativo, redefiniendo así las métricas de excelencia para la educación superior.
Claudia Ayoubi, Patrick Tabchoury, Henri Savall   +2 more
doaj  

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

GOBERNANZA Y COORDINACIÓN EN LA CADENA DE LA CARNE BOVINA: FOCALIZACIÓN EN EL SUDOESTE BONAERENSE

Costos y Gestión, 2021
La investigación analiza aspectos institucionales de la ganadería del sudoeste bonaerense como red interorganizacional, identificando actores relevantes del campo organizacional y el tipo de vínculos que mantienen entre ellos.
Marianela De Batista
doaj  

BANKRUPTCY COSTS, DILUTION COSTS AND STOCK MARKET DEVELOPMENT [PDF]

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Salvatore Capasso
core  

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

Molecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck, Nele De Meulenaere, Thomas Vanpoucke, Joe Ibrahim, Dieter Peeters, Suresh Krishan Yogeswaran, Wen Wen, Paul Van Schil, Jeroen M. H. Hendriks, Jo Raskin, Jan van Meerbeeck, Guy Van Camp, Ken Op de Beeck   +12 more
wiley   +1 more source

Costeo y toma de decisiones en el agro: una propuesta aplicada

Costos y Gestión
La dinámica productiva de las empresas agropecuarias se caracteriza por una alta incertidumbre climática, ciclos biológicos extensos y una débil correlación entre costos, precios y volúmenes de producción.
Jorge Luis Paturlanne, Rocio Lujan Gonzalez, Santiago Agustín Perez, Santiago Ferro Moreno   +3 more
doaj   +1 more source

EL ANÁLISIS MARGINAL EN LA INDUSTRIA AUTOMOTRIZ

Costos y Gestión, 2021
La industria automotriz en Argentina está pasando por un momento crítico por la crisis macroeconómica que está afrontando el país, con lo cual para poder sobrevivir a esta situación buscan herramientas que le brinden información crítica a la hora de ...
Fabrizio Sachetto
doaj  

Endogenous Transaction Costs [PDF]

The paper proposes an alternative general equilibrium formulation of financial asset economies with transactions costs. Transaction costs emerge endogenously at equilibrium and reflect agents decisions of intermediating financial activities at the ...
Martins-da-Rocha, Victor Filipe, Vailakis, Yiannis   +1 more
core  

Strength through diversity: how cancers thrive when clones cooperate

Molecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken, Maartje Witsen, Emile E. Voest, Krijn K. Dijkstra   +3 more
wiley   +1 more source