Results 1 to 10 of about 84,630 (262)
The effect of preoperative sodium-glucose cotransporter 2 inhibitors on the incidence of perioperative metabolic acidosis: A retrospective cohort study [PDF]
BMC Endocrine Disorders, 2022 Background Sodium-glucose cotransporter 2 inhibitors are a novel class of anti-hyperglycemic agents. Although several cases of perioperative euglycemic diabetic ketoacidosis have been linked to these medications, the association remains unclear.
Yudai Iwasaki +6 more
doaj +2 more sources
Frontiers in Cardiovascular Medicine, 2023 PurposeTo describe the efficacy and safety of sodium-glucose cotransporter 2 inhibitors as a specific treatment for anthracycline-related cardiac dysfunction in a small real-world population.MethodsSeven patients with anthracycline-related cardiac ...
Francesco Giangiacomi +13 more
doaj +1 more source
A trafficking-deficient mutant of KCC3 reveals dominant-negative effects on K-Cl cotransport function. [PDF]
PLoS ONE, 2013 The K-Cl cotransporter (KCC) functions in maintaining chloride and volume homeostasis in a variety of cells. In the process of cloning the mouse KCC3 cDNA, we came across a cloning mutation (E289G) that rendered the cotransporter inactive in functional ...
Jinlong Ding +2 more
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Frontiers in Endocrinology, 2023 Background and aimsOutcome trials using sodium glucose cotransporter type 2 inhibitors have consistently shown their potential to preserve kidney function in diabetic and nondiabetic patients. Several mechanisms have been introduced which may explain the
Emma S. Speedtsberg +5 more
doaj +1 more source
Decreased chloride channel expression in the dorsolateral prefrontal cortex in schizophrenia. [PDF]
PLoS ONE, 2015 Alterations in GABAergic neurotransmission are implicated in several psychiatric illnesses, including schizophrenia. The Na-K-Cl and K-Cl cotransporters regulate intracellular chloride levels.
Courtney R Sullivan +4 more
doaj +1 more source
Journal of Medical Case Reports, 2021 Background Euglycemic diabetic ketoacidosis is an uncommon but life-threatening complication associated with the use of sodium-glucose cotransporter 2 inhibitors that causes lower than expected blood glucose levels typically seen in diabetic ketoacidosis.
Brian Vadasz +4 more
doaj +1 more source
NTCP Change in Rats of Hilar Cholangiocarcinoma and Therapeutic Significance
Technology in Cancer Research & Treatment, 2022 Background: The study aims to detect the expression of Na + /taurocholate cotransporter polypeptide in hilar cholangiocarcinoma of rat model, to provide a new therapeutic target for gene therapy of hilar cholangiocarcinoma.
Meng-yu Zhang MD +4 more
doaj +1 more source
Regulators of Slc4 bicarbonate transporter activity
Frontiers in Physiology, 2015 The Slc4 family of transporters is comprised of anion exchangers (AE1-4), Na-coupled bicarbonate transporters (NCBTs) including electrogenic Na/bicarbonate cotransporters (NBCe1 and NBCe2), electroneutral Na/bicarbonate cotransporters (NBCn1 and NBCn2 ...
Ian M. Thornell, Mark Oliver Bevensee
doaj +1 more source
Safety of sodium–glucose cotransporter 2 inhibitors in Asian type 2 diabetes populations
Journal of Diabetes Investigation, 2023 The prevalence of type 2 diabetes mellitus continues to increase in many Asian countries, with possible contributing factors, such as younger‐onset disease, diabetes development at lower body mass index, higher visceral fat accumulation and poorer β‐cell
Jaime A Davidson +4 more
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Journal of Diabetes Investigation, 2022 The present retrospective study aimed to identify factors associated with an increased risk of acute kidney injury in Japanese patients with type 2 diabetes treated with sodium–glucose cotransporter 2 inhibitors.
Takeshi Horii +4 more
doaj +1 more source