Results 1 to 10 of about 62,637 (200)

Sodium‐Glucose Cotransporter 2 Inhibition for the Prevention of Cardiovascular Events in Patients With Type 2 Diabetes Mellitus: A Systematic Review and Meta‐Analysis

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2020
Background Several trials have demonstrated protective effects from inhibition of sodium‐glucose cotransporter 2 among patients with type 2 diabetes mellitus.
Clare Arnott, Qiang Li, Amy Kang, Brendon L. Neuen, Severine Bompoint, Carolyn S. P. Lam, Anthony Rodgers, Kenneth W. Mahaffey, Christopher P. Cannon, Vlado Perkovic, Meg J. Jardine, Bruce Neal   +11 more
doaj   +2 more sources

The protective effect of sodium-glucose cotransporter-2 inhibitor on left ventricular global longitudinal strain in patients with type 2 diabetes mellitus according to disease duration [PDF]

Scientific Reports
Our study aimed to elucidate the impact of sodium-glucose cotransporter-2 inhibitor on left ventricular systolic function using global longitudinal strain in type 2 diabetes mellitus patients and to assess its protective effect depending on disease ...
Ziying Wang, Long Huang, Leilei Han, Xiangsui Hu, Mingyi Dong, Chunquan Zhang, Liangyun Guo, Shengbo Liu, Lingmin Liao   +8 more
doaj   +2 more sources

Perioperative euglycemic DKA: The YIN and YANG of sodium-glucose cotransporter 2 inhibitors [PDF]

Journal of Anaesthesiology Clinical Pharmacology
Sodium-glucose cotransporter 2 inhibitors are gaining widespread acceptance in managing diabetic patients due to their favorable cardiac and renal protective effects.
Shilpushp Bhosale, Akash Golani, Malini Premkumar Joshi, Atul Prabhakar Kulkarni   +3 more
doaj   +2 more sources

Association of Race/Ethnicity, Gender, and Socioeconomic Status With Sodium-Glucose Cotransporter 2 Inhibitor Use Among Patients With Diabetes in the US

JAMA Network Open, 2021
This cohort study evaluates whether inequities in race/ethnicity, gender, and socioeconomic status exist in sodium-glucose cotransporter 2 (SGLT2) inhibitor use among US patients with type 2 diabetes.
L. Eberly, Lin Yang, N. Eneanya, U. Essien, H. Julien, Ashwin S. Nathan, S. Khatana, E. Dayoub, Alexander C. Fanaroff, Jay Giri, P. Groeneveld, S. Adusumalli   +11 more
semanticscholar   +1 more source

Case report: Sodium-glucose cotransporter 2 inhibitors induce left ventricular reverse remodeling in anthracycline-related cardiac dysfunction—a case series

Frontiers in Cardiovascular Medicine, 2023
PurposeTo describe the efficacy and safety of sodium-glucose cotransporter 2 inhibitors as a specific treatment for anthracycline-related cardiac dysfunction in a small real-world population.MethodsSeven patients with anthracycline-related cardiac ...
Francesco Giangiacomi, Francesco Giangiacomi, Andrea Faggiano, Andrea Faggiano, Daniela Cardinale, Francesca Gaia Rossi, Alberto Pollina, Elisa Gherbesi, Eleonora Gnan, Eleonora Gnan, Stefano Carugo, Stefano Carugo, Marco Vicenzi, Marco Vicenzi   +13 more
doaj   +1 more source

Sodium-Glucose Cotransporter 2 Inhibitors Mechanisms of Action: A Review

Frontiers in Medicine, 2021
Sodium-Glucose Cotransporter 2 inhibitors (SGLT2i), or gliflozins, are a group of antidiabetic drugs that have shown improvement in renal and cardiovascular outcomes in patients with kidney disease, with and without diabetes.
Jorge I. Fonseca-Correa, R. Correa-Rotter   +1 more
semanticscholar   +1 more source

A trafficking-deficient mutant of KCC3 reveals dominant-negative effects on K-Cl cotransport function. [PDF]

PLoS ONE, 2013
The K-Cl cotransporter (KCC) functions in maintaining chloride and volume homeostasis in a variety of cells. In the process of cloning the mouse KCC3 cDNA, we came across a cloning mutation (E289G) that rendered the cotransporter inactive in functional ...
Jinlong Ding, José Ponce-Coria, Eric Delpire   +2 more
doaj   +1 more source

The effect of preoperative sodium-glucose cotransporter 2 inhibitors on the incidence of perioperative metabolic acidosis: A retrospective cohort study

BMC Endocrine Disorders, 2022
Background Sodium-glucose cotransporter 2 inhibitors are a novel class of anti-hyperglycemic agents. Although several cases of perioperative euglycemic diabetic ketoacidosis have been linked to these medications, the association remains unclear.
Yudai Iwasaki, Yusuke Sasabuchi, Sho Horikita, Taku Furukawa, Junji Shiotsuka, Alan Kawarai Lefor, Masamitsu Sanui   +6 more
doaj   +1 more source

Narrative review investigating the nephroprotective mechanisms of sodium glucose cotransporter type 2 inhibitors in diabetic and nondiabetic patients with chronic kidney disease

Frontiers in Endocrinology, 2023
Background and aimsOutcome trials using sodium glucose cotransporter type 2 inhibitors have consistently shown their potential to preserve kidney function in diabetic and nondiabetic patients. Several mechanisms have been introduced which may explain the
Emma S. Speedtsberg, Emma S. Speedtsberg, Emma S. Speedtsberg, Martin Tepel, Martin Tepel, Martin Tepel   +5 more
doaj   +1 more source

Decreased chloride channel expression in the dorsolateral prefrontal cortex in schizophrenia. [PDF]

PLoS ONE, 2015
Alterations in GABAergic neurotransmission are implicated in several psychiatric illnesses, including schizophrenia. The Na-K-Cl and K-Cl cotransporters regulate intracellular chloride levels.
Courtney R Sullivan, Adam J Funk, Dan Shan, Vahram Haroutunian, Robert E McCullumsmith   +4 more
doaj   +1 more source