Results 121 to 130 of about 95,583 (387)
ESC Heart Failure, Volume 12, Issue 2, Page 1151-1165, April 2025.Prediction of LVEF improvement in patients with HFrEF and HFmrEF following treatment with Sacubitril/Valsartan. Workflow of this study investigating the functional capacity improvement in response to Sacubitrail/Valsartsan in a real‐world scenario of heart failure treatment.
Florian Appenzeller +8 more
wiley +1 more source
Journal of Lipid Research, 1999 To design a reliable 3D QSAR model of the intestinal Na+/bile acid cotransporter, we have used a training set of 17 inhibitors of the rabbit ileal Na+/bile acid cotransporter.
Karl-Heinz Baringhaus +3 more
doaj
Sodium-glucose cotransporter 2 inhibitor for the treatment of diabetic nephropathy
Linchuang shenzangbing zazhi, 2021 As one of the most common microvascular complications of diabetes mellitus, diabetic nephropathy（DN）is a common cause of end-stage renal disease（ESRD）.Sodium-glucose cotransporter 2（SGLT-2）inhibitor, a new type of hypoglycemic agent, may effectively ...
Kong Ling-li +4 more
doaj
Energy Balance After Sodium–Glucose Cotransporter 2 Inhibition
Diabetes Care, 2015 OBJECTIVE Sodium–glucose cotransporter 2 (SGLT2) inhibitors cause substantially less weight loss than expected from the energy excreted via glycosuria. Our aim was to analyze this phenomenon quantitatively. RESEARCH DESIGN AND METHODS Eighty-six patients
G. Ferrannini +5 more
semanticscholar +1 more source
Dapagliflozin stimulates glucagon secretion at high glucose: experiments and mathematical simulations of human A-cells. [PDF]
, 2016 Glucagon is one of the main regulators of blood glucose levels and dysfunctional stimulus secretion coupling in pancreatic A-cells is believed to be an important factor during development of diabetes.
Ahlstedt, I. +3 more
core +1 more source
The apical NKCC1 cotransporter debate
The FASEB Journal, 2012 Choroid plexus epithelial cells (CPECs) secrete cerebrospinal fluid (CSF) and regulate its electrolyte composition. CPECs express Na+/K+ ATPase and Na+‐K+‐2Cl− cotransporter 1 (NKCC1) on their apical membrane (CSF‐facing), deviating from typical basolateral membrane location in secretory epithelia.
Crum, Jeannine Marie +2 more
openaire +2 more sources
The effects of sodium–glucose cotransporter 2 inhibitors on the ‘forgotten’ right ventricle
ESC Heart Failure, Volume 12, Issue 2, Page 1045-1058, April 2025.Abstract With the progress in diagnosis, treatment and imaging techniques, there is a growing recognition that impaired right ventricular (RV) function profoundly affects the prognosis of patients with heart failure (HF), irrespective of their left ventricular ejection fraction (LVEF).
Liangzhen Qu, Xueting Duan, Han Chen
wiley +1 more source
Segment-specific expression of 2P domain potassium channel genes in human nephron. [PDF]
, 2004 BackgroundThe 2P domain potassium (K2P) channels are a recently discovered ion channel superfamily. Structurally, K2P channels are distinguished by the presence of two pore forming loops within one channel subunit. Functionally, they are characterized by
Bockenhauer, Detlef +3 more
core +1 more source
Implementation of guideline‐recommended medical therapy for patients with heart failure in Europe
ESC Heart Failure, Volume 12, Issue 2, Page 790-798, April 2025.Abstract Physicians' adherence to guideline‐recommended heart failure (HF) treatment remains suboptimal, especially regarding the target doses. In particular, there is evidence that non‐cardiologists are less compliant with HF guideline recommendations. This is likely to have a detrimental impact on patients' survival, readmissions and quality of life.
Maurizio Volterrani +11 more
wiley +1 more source
Journal of Diabetes Investigation, 2020 Type A insulin resistance (IR) syndrome is a severe IR form caused by insulin receptor (INSR) gene defects. Antidiabetic drugs, including high‐dose insulin and insulin‐sensitizing agents, often fail to control associated hyperglycemia.
Shuichi Nagashima +6 more
doaj +1 more source