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Sodium Chloride Cotransporter in Hypertension
BiomedicinesThe sodium chloride cotransporter (NCC) is essential for electrolyte balance, blood pressure regulation, and pathophysiology of hypertension as it mediates the reabsorption of ultrafiltered sodium in the renal distal convoluted tubule.
Annalisa Castagna +6 more
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Cotransport of water by the Na + /glucose cotransporter [PDF]
Proceedings of the National Academy of Sciences, 1996 Water is transported across epithelial membranes in the absence of any hydrostatic or osmotic gradients. A prime example is the small intestine, where 10 liters of water are absorbed each day. Although water absorption is secondary to active solute transport, the coupling mechanism between solute and water flow is not understood.
Loo, D.D.F. +3 more
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Current status of liver transplantation for non‐B non‐C liver cirrhosis and hepatocellular carcinoma
Annals of Gastroenterological Surgery, Volume 7, Issue 1, Page 42-52, January 2023., 2023 Recently, the cases of LT for non‐B non‐C cirrhosis and HCC have been increasing in Japan as well as worldwide. Perioperative management of non‐B non‐C liver disease is problematic due to various risk factors, including alcohol consumption and metabolic syndrome‐related risks, such as obesity and diabetes mellitus.
Takahiro Nishio +4 more
wiley +1 more source
Advances in the pathogenesis of Rett syndrome using cell models
Animal Models and Experimental Medicine, Volume 5, Issue 6, Page 532-541, December 2022., 2022 Most Rett syndrome (RTT) patients are affected by the MECP2 gene mutations. And the mutations of MECP2 have wide effects on different cell types of nervous system, including neurons, astrocytes, oligodendrocytes and microglia, which always combined together to lead to abnormalities in the whole neural network.
Sijia Lu, Yongchang Chen, Zhengbo Wang
wiley +1 more source
Sodium-glucose cotransport [PDF]
Current Opinion in Nephrology and Hypertension, 2015 Sodium-glucose cotransporters (SGLTs) are important mediators of glucose uptake across apical cell membranes. SGLT1 mediates almost all sodium-dependent glucose uptake in the small intestine, while in the kidney SGLT2, and to a lesser extent SGLT1, account for more than 90% and nearly 3%, respectively, of glucose reabsorption from the glomerular ...
Poulsen, Søren Brandt +2 more
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JAMA Internal Medicine, 2021 Key Points Question What is the comparative effectiveness of sodium-glucose cotransporter 2 inhibitors vs sulfonylureas associated with the risk of all-cause mortality among individuals using metformin for treatment of type 2 diabetes?
Yan Xie +5 more
semanticscholar +1 more source
Clinical Cardiology, Volume 45, Issue 12, Page 1287-1296, December 2022., 2022 Abstract Background Type 2 diabetes mellitus (T2DM) patients may have cardiac remodeling and dysfunction from the early stage of disease. This study aimed to determine the association between cystatin C (CysC) and early cardiac functional or structural impairment in T2DM patients without renal dysfunction.
Zhuoshan Huang +10 more
wiley +1 more source
Journal of Medical Case Reports, 2021 Background Euglycemic diabetic ketoacidosis is an uncommon but life-threatening complication associated with the use of sodium-glucose cotransporter 2 inhibitors that causes lower than expected blood glucose levels typically seen in diabetic ketoacidosis.
Brian Vadasz +4 more
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Equilibrium Properties of E. coli Lactose Permease Symport -- A Random-walk Model Approach [PDF]
, 2021 The symport of lactose and H+ is an important physiological process in E. coli, for it is closely related to cellular energy supply. In this paper, the symport of H+ and lactose by E. coli LacY protein is computationally simulated using a newly proposed cotransport model that takes the "leakage" phenomenon (uncoupled sugar translocation) into account ...
arxiv +1 more source
Urea transport by cotransporters [PDF]
The Journal of Physiology, 2000 The rabbit Na+-glucose cotransporter (rbSGLT1) was expressed in Xenopus laevis oocytes and urea transport in rbSGLT1 and non-injected (control) oocytes was studied using [14C]urea as a tracer. The level of rbSGLT1 expression in these batches of oocytes was monitored by measuring the uptake of alpha-methyl-D-[14C]glucopyranoside ([14C]alphaMDG).
Daisy W. Leung +4 more
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