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Sodium Chloride Cotransporter in Hypertension
BiomedicinesThe sodium chloride cotransporter (NCC) is essential for electrolyte balance, blood pressure regulation, and pathophysiology of hypertension as it mediates the reabsorption of ultrafiltered sodium in the renal distal convoluted tubule.
Annalisa Castagna +6 more
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Cotransport of water by the Na + /glucose cotransporter [PDF]
Proceedings of the National Academy of Sciences, 1996 Water is transported across epithelial membranes in the absence of any hydrostatic or osmotic gradients. A prime example is the small intestine, where 10 liters of water are absorbed each day. Although water absorption is secondary to active solute transport, the coupling mechanism between solute and water flow is not understood.
Loo, D.D.F. +3 more
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Sodium-glucose cotransport [PDF]
Current Opinion in Nephrology and Hypertension, 2015 Sodium-glucose cotransporters (SGLTs) are important mediators of glucose uptake across apical cell membranes. SGLT1 mediates almost all sodium-dependent glucose uptake in the small intestine, while in the kidney SGLT2, and to a lesser extent SGLT1, account for more than 90% and nearly 3%, respectively, of glucose reabsorption from the glomerular ...
Poulsen, Søren Brandt +2 more
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JAMA Internal Medicine, 2021 Key Points Question What is the comparative effectiveness of sodium-glucose cotransporter 2 inhibitors vs sulfonylureas associated with the risk of all-cause mortality among individuals using metformin for treatment of type 2 diabetes?
Yan Xie +5 more
semanticscholar +1 more source
Decreased chloride channel expression in the dorsolateral prefrontal cortex in schizophrenia. [PDF]
PLoS ONE, 2015 Alterations in GABAergic neurotransmission are implicated in several psychiatric illnesses, including schizophrenia. The Na-K-Cl and K-Cl cotransporters regulate intracellular chloride levels.
Courtney R Sullivan +4 more
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Cryo-EM structure of the potassium-chloride cotransporter KCC4 in lipid nanodiscs. [PDF]
, 2020 Cation-chloride-cotransporters (CCCs) catalyze transport of Cl- with K+ and/or Na+across cellular membranes. CCCs play roles in cellular volume regulation, neural development and function, audition, regulation of blood pressure, and renal function.
Brohawn, Stephen Graf +2 more
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Urea transport by cotransporters [PDF]
The Journal of Physiology, 2000 The rabbit Na+-glucose cotransporter (rbSGLT1) was expressed in Xenopus laevis oocytes and urea transport in rbSGLT1 and non-injected (control) oocytes was studied using [14C]urea as a tracer. The level of rbSGLT1 expression in these batches of oocytes was monitored by measuring the uptake of alpha-methyl-D-[14C]glucopyranoside ([14C]alphaMDG).
Daisy W. Leung +4 more
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Journal of Medical Case Reports, 2021 Background Euglycemic diabetic ketoacidosis is an uncommon but life-threatening complication associated with the use of sodium-glucose cotransporter 2 inhibitors that causes lower than expected blood glucose levels typically seen in diabetic ketoacidosis.
Brian Vadasz +4 more
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NTCP Change in Rats of Hilar Cholangiocarcinoma and Therapeutic Significance
Technology in Cancer Research & Treatment, 2022 Background: The study aims to detect the expression of Na + /taurocholate cotransporter polypeptide in hilar cholangiocarcinoma of rat model, to provide a new therapeutic target for gene therapy of hilar cholangiocarcinoma.
Meng-yu Zhang MD +4 more
doaj +1 more source
Safety of sodium–glucose cotransporter 2 inhibitors in Asian type 2 diabetes populations
Journal of Diabetes Investigation, 2023 The prevalence of type 2 diabetes mellitus continues to increase in many Asian countries, with possible contributing factors, such as younger‐onset disease, diabetes development at lower body mass index, higher visceral fat accumulation and poorer β‐cell
Jaime A Davidson +4 more
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