Results 21 to 30 of about 95,583 (387)
Regulation of the Renal NaCl Cotransporter and Its Role in Potassium Homeostasis.
Physiological Reviews, 2020 Daily dietary potassium (K+) intake may be as large as the extracellular K+ pool. To avoid acute hyperkalemia, rapid removal of K+ from the extracellular space is essential.
E. Hoorn +3 more
semanticscholar +1 more source
Regulators of Slc4 bicarbonate transporter activity
Frontiers in Physiology, 2015 The Slc4 family of transporters is comprised of anion exchangers (AE1-4), Na-coupled bicarbonate transporters (NCBTs) including electrogenic Na/bicarbonate cotransporters (NBCe1 and NBCe2), electroneutral Na/bicarbonate cotransporters (NBCn1 and NBCn2 ...
Ian M. Thornell, Mark Oliver Bevensee
doaj +1 more source
Sodium–glucose cotransporter 2 inhibitor Dapagliflozin attenuates diabetic cardiomyopathy
Cardiovascular Diabetology, 2020 Diabetes mellitus type 2 (DM2) is a risk factor for developing heart failure but there is no specific therapy for diabetic heart disease. Sodium glucose transporter 2 inhibitors (SGLT2I) are recently developed diabetic drugs that primarily work on the ...
M. Arow +13 more
semanticscholar +1 more source
An emerging protagonist: Sodium Glucose Co-transporters (SGLTs) as a burgeoning target for the treatment of diabetes mellitus [PDF]
, 2012 Contemporary therapies to rationalize the hyperglycaemia in type 2 diabetes mellitus (T2DM) generally involve insulin-dependent mechanisms and lose their effectiveness as pancreatic b-cell function decreases to a greater extent. The kidney emerges out as
Danish Ahmed +3 more
core +2 more sources
A novel delta current method for transport stoichiometry estimation. [PDF]
, 2014 BackgroundThe ion transport stoichiometry (q) of electrogenic transporters is an important determinant of their function. q can be determined by the reversal potential (Erev) if the transporter under study is the only electrogenic transport mechanism or ...
Kao, Liyo, Kurtz, Ira, Shao, Xuesi M
core +1 more source
Journal of Diabetes Investigation, 2022 The present retrospective study aimed to identify factors associated with an increased risk of acute kidney injury in Japanese patients with type 2 diabetes treated with sodium–glucose cotransporter 2 inhibitors.
Takeshi Horii +4 more
doaj +1 more source
Circulation, 2016 Sodium-glucose cotransporter-2 (SGLT2) inhibitors, including empagliflozin, dapagliflozin, and canagliflozin, are now widely approved antihyperglycemic therapies. Because of their unique glycosuric mechanism, SGLT2 inhibitors also reduce weight.
H. Heerspink +4 more
semanticscholar +1 more source
SGLT-2 Inhibitors: A Novel Mechanism in Targeting Glycemic Control in Type 2 Diabetes Mellitus [PDF]
, 2016 OBJECTIVE: To review the chemistry, pharmacology, pharmacodynamics, pharmacokinetics, clinical efficacy, tolerability, dosing, drug interactions, and administration of canagliflozin, dapagliflozin, and empagliflozin, and comparing the benefit and risk ...
Ahmed-Sarwar, Nabila +2 more
core +2 more sources
Diabetes Care, 2019 Sodium–glucose cotransporter (SGLT) inhibitors are new oral antidiabetes medications shown to effectively reduce glycated hemoglobin (A1C) and glycemic variability, blood pressure, and body weight without intrinsic properties to cause hypoglycemia in ...
T. Danne +31 more
semanticscholar +1 more source
Frontiers in Cellular Neuroscience, 2023 K+/Cl− cotransporter 2 (KCC2) is a major Cl− extruder in mature neurons and is responsible for the establishment of low intracellular [Cl−], necessary for fast hyperpolarizing GABAA-receptor mediated synaptic inhibition.
Abhishek Pethe +7 more
doaj +1 more source