Results 21 to 30 of about 84,630 (262)
Cell volume regulation in the proximal tubule of rat kidney proximal tubule cell volume regulation [PDF]
, 2017 We developed a dynamic model of a rat proximal convoluted tubule cell in order to investigate cell volume regulation mechanisms in this nephron segment.
Edwards, Aurelie, Layton, Anita T.
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Urinary tract infections in patients with type 2 diabetes mellitus with pharmacological glucosuria
Терапевтический архив, 2020 Selective inhibitors of sodium-glucose cotransporter belong to a new class of drugs for the treatment of type 2 diabetes mellitus. The mechanism of their action is based on insulin-independent reduction of glucose reabsorption in the proximal renal ...
N. V. Sturov +3 more
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Kidney International, 1989 The KCl cotransporter in the basolateral membrane of renal tubules may play a central role in the transcellular transport of NaCl. Because this transporter is electrically neutral, and also functions in parallel to the electrogenic Na,K-ATPase, there is an imbalance in charge which must be expressed as a cationic current across the basolateral membrane.
Warnock, David G., Eveloff, Jill
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The SGLT2 inhibitor empagliflozin for the treatment of type 2 diabetes mellitus: A bench to bedside review [PDF]
, 2014 INTRODUCTION: The treatment of type 2 diabetes mellitus (T2DM) continues to pose challenges for clinicians and patients. The dramatic rise in T2DM prevalence, which has paralleled the rise in obesity, has strained the healthcare system and prompted the ...
McGill, Janet B
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Active site voltage clamp fluorometry of the sodium glucose cotransporter hSGLT1. [PDF]
, 2017 In the human sodium glucose cotransporter (hSGLT1) cycle, the protein undergoes conformational changes where the sugar-binding site alternatively faces the external and internal surfaces.
Gorraitz, Edurne +4 more
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Cell Reports, 2019 Summary: It is generally thought that hippocampal neurons of perinatal rats and mice lack transport-functional K-Cl cotransporter KCC2, and that Cl− regulation is dominated by Cl− uptake via the Na-K-2Cl cotransporter NKCC1. Here, we demonstrate a robust
Inkeri Spoljaric +5 more
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Kidney International, 1996 Two non-homologous proximal tubular apical Na/Pi-cotransport systems (type I and type II) have been identified thus far by expression cloning. Subsequent studies provided evidence that the type II Na/Pi-cotransporter represents a target for the physiological and pathophysiological regulation of proximal reabsorption of phosphate.
Biber, J +7 more
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Journal of Diabetes Investigation, 2019 Cardiorenal protective effects of sodium–glucose cotransporter 2 inhibitors are difficult to explain. From the recent works by Takagi et al. and an expert consensus report, I suggest further works on the effects of sodium–glucose cotransporter ...
Hong Kyu Lee
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Structure-function relationships in the sodium chloride cotransporter
Frontiers in Physiology, 2023 The thiazide sensitive Na+:Cl− cotransporter (NCC) is the principal via for salt reabsorption in the apical membrane of the distal convoluted tubule (DCT) in mammals and plays a fundamental role in managing blood pressure.
Erika Moreno +6 more
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Role of physiological ClC-1 Cl- ion channel regulation for the excitability and function of working skeletal muscle. [PDF]
, 2016 Electrical membrane properties of skeletal muscle fibers have been thoroughly studied over the last five to six decades. This has shown that muscle fibers from a wide range of species, including fish, amphibians, reptiles, birds, and mammals, are all ...
Chen, Tsung-Yu +4 more
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