Results 301 to 310 of about 62,786 (347)
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Current Opinion in Cell Biology, 1996
Recent studies of cloned mammalian sodium cotransporters in heterologous systems have revealed that these integral membrane proteins serve multiple functions as cotransporters, uniporters, channels and water transporters. Some progress has been gained in understanding their secondary structure, but information on helical bundling and tertiary structure
E M, Wright +3 more
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Recent studies of cloned mammalian sodium cotransporters in heterologous systems have revealed that these integral membrane proteins serve multiple functions as cotransporters, uniporters, channels and water transporters. Some progress has been gained in understanding their secondary structure, but information on helical bundling and tertiary structure
E M, Wright +3 more
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The overshoot phenomenon in cotransport
Biochimica et Biophysica Acta (BBA) - Biomembranes, 1984Based on simplified equations, the overshoot curve experimentally observed with Na+-linked cotransport of neutral substrate (sugars or amino acids) has been simulated by computer. The approach is in principle similar to that of previous approaches (Weiss, S.D., McNamara, P.D. and Segal, S. (1981) J. Theor. Biol.
Alan M. Weinstein, Erich Heinz
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Current Opinion in Cell Biology, 1992
Significant advances have been made in elucidating the structure of Na+ cotransport proteins. Some fifteen of these low-abundance proteins have been cloned, sequenced and functionally expressed. They are members of the 12 membrane-spanning superfamily and they segregate into two groups, the Na+/glucose (SGLT1) and Na+/Cl-/GABA (GAT-1) families.
Karl M. Hager +2 more
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Significant advances have been made in elucidating the structure of Na+ cotransport proteins. Some fifteen of these low-abundance proteins have been cloned, sequenced and functionally expressed. They are members of the 12 membrane-spanning superfamily and they segregate into two groups, the Na+/glucose (SGLT1) and Na+/Cl-/GABA (GAT-1) families.
Karl M. Hager +2 more
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JAMA cardiology, 2017
Importance Only 1 class of glucose-lowering agents—sodium-glucose cotransporter 2 (SGLT2) inhibitors—has been reported to decrease the risk of cardiovascular events primarily by reducing the risk of the development or progression of heart failure.
M. Packer +4 more
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Importance Only 1 class of glucose-lowering agents—sodium-glucose cotransporter 2 (SGLT2) inhibitors—has been reported to decrease the risk of cardiovascular events primarily by reducing the risk of the development or progression of heart failure.
M. Packer +4 more
semanticscholar +1 more source
Current Opinion in Cell Biology, 1990
Transport systems for low-molecular-weight solutes are generally divided into two groups: those that are driven directly by chemical reactions (e.g. ATP hydrolysis, photolysis), and those that are coupled to gradients established by the primary chemical event.
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Transport systems for low-molecular-weight solutes are generally divided into two groups: those that are driven directly by chemical reactions (e.g. ATP hydrolysis, photolysis), and those that are coupled to gradients established by the primary chemical event.
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Sodium–Glucose Cotransporter 2 Inhibition and Diabetic Kidney Disease
Diabetes, 2019Diabetic kidney disease (DKD) is now the principal cause of chronic kidney disease leading to end-stage kidney disease worldwide. As a primary contributor to the excess risk of all-cause and cardiovascular death in diabetes, DKD is a major contributor to
R. Alicic +4 more
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The thermostatics and thermodynamics of cotransport
Biochimica et Biophysica Acta (BBA) - Biomembranes, 1984The thermostatics of cotransport are reviewed. A static-head equilibrium state across a cotransport system, without leaks, is thought to occur when the electrochemical potential of the driven solute, B prevents net flow of the driving solute, A. For a symport this gives the relationship (formula: see text) Where n is the stoichiometric coefficient ...
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Renal sodium-phosphate cotransport
Current Opinion in Nephrology and Hypertension, 1994Proximal tubular reabsorption of inorganic phosphate (P(i) is a major determinant of the extracellular concentration of phosphate. The net proximal reabsorption of phosphate largely depends on the rate of apical sodium-dependent transport of P(i) (Na/P(i) cotransport), which is controlled by various hormonal and nonhormonal factors.
J Biber, Heini Murer
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Random-walk model of cotransport
Physical Review E, 2020We present a statistical mechanical model to describe the dynamics of an arbitrary cotransport system. Our starting point was the alternating access mechanism, which suggests the existence of six states for the cotransport cycle. Then we determined the 14 transition probabilities between these states, including a leak pathway, and used them to write a ...
Yan B. Barreto +2 more
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Cotransport of phosphate and sodium by yeast
Biochimica et Biophysica Acta (BBA) - Biomembranes, 1977Phosphate uptake by yeast at pH 7.2 is mediated by two mechanisms, one of which has a Km of 30 micronM and is independent of sodium, and a sodium-dependent mechanism with a Km of 0.6 micronM, both Km values with respect to monovalent phosphate. The sodium-dependent mechanism has two sites with affinity for Na+, with affinity constants of 0.04 and 29 mM.
G.M. Roomans +2 more
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