Results 301 to 310 of about 95,583 (387)

Safety and tolerability of a 5 mg starting dose of vericiguat among patients with heart failure: The VELOCITY study

open access: yesEuropean Journal of Heart Failure, EarlyView.
ABSTRACT Aims In clinical practice, simplifying the number of medication titration steps while maintaining safety may improve the likelihood of patients with heart failure (HF) achieving target doses of guideline‐directed medical therapy (GDMT).
Stephen J. Greene   +8 more
wiley   +1 more source

Renal denervation improves cardiac function and exercise duration in a miniswine model of heart failure with preserved ejection fraction

open access: yesEuropean Journal of Heart Failure, EarlyView.
ABSTRACT Aims Overactivity of the sympathetic nervous system is a common underlying mechanism in development and progression of several heart failure with preserved ejection fraction (HFpEF) comorbidities. Decreasing renal sympathetic nerve activity using catheter‐based renal denervation (RDN) systems have shown efficacy in treating resistant ...
David J. Lefer   +6 more
wiley   +1 more source

The crosstalk between immune activation and metabolism in heart failure. A scientific statement of the Heart Failure Association of the ESC

open access: yesEuropean Journal of Heart Failure, EarlyView.
Abstract A better understanding of additional mechanisms of heart failure (HF) progression may allow a different and more complete phenotyping of the disease and identification of novel therapeutic targets. Persistent latent myocardial inflammation/immune activation in HF may represent an attempt to restore tissue homeostasis in the failing heart ...
Gabriele Fragasso   +20 more
wiley   +1 more source

Mechanical unloading is accompanied by reverse metabolic remodelling in the failing heart: Identification of a novel citraconate‐mediated pathway

open access: yesEuropean Journal of Heart Failure, EarlyView.
Aims Although functional recovery of the failing heart with left ventricular assist device (LVAD) unloading can occur, the underpinning mechanism is unclear. We aimed to characterize the effect of myocardial biochemical effect of LVAD support in vivo and in vitro.
David M. Kaye   +15 more
wiley   +1 more source

Global heart failure epidemiology versus enrolment in pivotal trials: A formidable mismatch

open access: yesEuropean Journal of Heart Failure, EarlyView.
Abstract Aims Randomized clinical trials (RCTs) that inform international clinical practice guidelines should adequately represent regions burdened with disease. We aimed to assess the geographic representativeness of pivotal heart failure (HF) RCTs using two methodological approaches.
Guillaume Baudry   +8 more
wiley   +1 more source

Are There Any Renoprotective Effects of SGLT2 Inhibitors in Heart Transplant Recipients with Diabetes? [PDF]

open access: yesActa Cardiol Sin
Lu YM   +6 more
europepmc   +1 more source

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