Results 311 to 320 of about 62,786 (347)

[16] Cation-anion cotransport

1989
Two methods have been described for the study of cation-chloride cotransport systems. The zero-trans efflux method is designed to determine stoichiometric relationships between cotransported ions under conditions where ion exchanges cannot occur. These exchanges (e.g., Na+/Na+, K+/K+) may occur as partial or incomplete reactions of a cotransport ...
Mark Haas, Thomas J. McManus
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Impact of sodium glucose cotransporter 2 inhibitor on histological features and glucose metabolism of non‐alcoholic fatty liver disease complicated by diabetes mellitus

Hepatology Research, 2019
The aim of this study was to investigate the therapeutic potential of sodium glucose cotransporter 2 inhibitor (SGLT2I) as an effective therapeutic option for non‐alcoholic fatty liver disease (NAFLD).
N. Akuta, Y. Kawamura, Chizuru Watanabe, Akihiro Nishimura, M. Okubo, Yasumichi Mori, Shunichiro Fujiyama, H. Sezaki, T. Hosaka, M. Kobayashi, M. Kobayashi, S. Saitoh, F. Suzuki, Yoshiyuki Suzuki, Y. Arase, K. Ikeda, H. Kumada   +16 more
semanticscholar   +1 more source

Analyzing an electrogenic cotransporter

The Journal of Membrane Biology, 1993
A model for the sodium-dependent accumulation of glutamate by synaptosomes has been presented which fits the data of Wheeler and his coworkers and supports their hypothesis of an electrogenic cotransporter. Since their hypothesis was based on experimental data on the operation of the cotransporter on the outer membrane, the model was expanded to ...
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Computational analysis of models for cotransport

Biochimica et Biophysica Acta (BBA) - Biomembranes, 1984
The order of substrate interaction with a cotransport carrier is studied by numerically fitting theoretical models to empirical data for a Na+-D-glucose pathway. Our analysis is based on a least-squares minimization routine developed at CERN, and uses data derived from tracer flux of substrate under equilibrium exchange conditions.
C.J. Lumsden, Michael Silverman, D.A. Harrison, G.W. Rowe   +3 more
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Molecular Mechanisms of NaCl Cotransport

Annual Review of Physiology, 1996
Electroneutral Na-(K)-Cl cotransporters are present in most cell types, where they play an important role in both sodium-chloride absorption and secretion and cell volume regulation. Recent advances in the molecular identification of these cotransporters have provided a new level of insight into the mechanisms of sodium-chloride-coupled cotransport and
M R Kaplan, D B Mount, E Delpire, G Gamba, S C Hebert   +4 more
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Regulation of Na+/Glucose Cotransporters

Journal of Experimental Biology, 1997
ABSTRACT Na+/glucose cotransporters (SGLTs) are expressed in the small intestine and the proximal renal tubule, where they play a central role in the absorption of glucose and galactose from food and the reabsorption of glucose from the glomerular filtrate.
Guido A. Zampighi, Donald D. F. Loo, J. R. Hirsch, Ernest M. Wright   +3 more
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Sodium–glucose cotransporter inhibitors and oxidative stress: An update

Journal of Cellular Physiology, 2018
Sodium–glucose cotransporter 2 (SGLT2) inhibitors are therapeutic agents that have been used recently to reduce tubular absorption of glucose, leading to enhanced glycosuria, resulting in the reduction of blood glucose and improved diabetes control ...
Habib Yaribeygi, S. Atkin, A. Butler, A. Sahebkar   +3 more
semanticscholar   +1 more source

Na+–sulfate cotransporter SLC13A1

Pflügers Archiv - European Journal of Physiology, 2013
Sulfate is essential for normal physiology. The kidney plays a major role in sulfate homeostasis. Sulfate is freely filtered and strongly reabsorbed in the proximal tubule. The apical membrane Na(+)-sulfate cotransporter NaS1 (SLC13A1) mediates sulfate (re)absorption across renal proximal tubule and small intestinal epithelia.
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Effects of the sodium‐glucose cotransporter 2 inhibitor dapagliflozin on fluid distribution: A comparison study with furosemide and tolvaptan

Nephrology, 2019
Sodium‐glucose cotransporter 2 (SGLT2) inhibitors are an antihyperglycemic drug with diuretic properties. We recently reported that an SGLT2 inhibitor ameliorated extracellular fluid expansion with a transient increase in urinary Na+ excretion.
Ken Ohara, Takahiro Masuda, Takuya Murakami, T. Imai, Hiromichi Yoshizawa, Saki Nakagawa, M. Okada, Atsushi Miki, Akihiro Myoga, T. Sugase, Chuji Sekiguchi, Yasuharu Miyazawa, A. Maeshima, T. Akimoto, O. Saito, S. Muto, D. Nagata   +16 more
semanticscholar   +1 more source

Renal potassium-chloride cotransporters

Current Opinion in Nephrology and Hypertension, 2001
The electroneutral cotransport of potassium and chloride is mediated by potassium-chloride transporters, which are encoded by members of the gene family of cation-chloride cotransporters. A significant body of evidence argues for swelling-activated, basolateral potassium-chloride transport in the proximal tubule and thick ascending limb, with a ...
Gerardo Gamba, David B. Mount
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