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Sodium-Potassium-Chloride Cotransport
Physiological Reviews, 2000Obligatory, coupled cotransport of Na+, K+, and Cl−by cell membranes has been reported in nearly every animal cell type. This review examines the current status of our knowledge about this ion transport mechanism. Two isoforms of the Na+-K+-Cl−cotransporter (NKCC) protein (∼120–130 kDa, unglycosylated) are currently known.
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American Journal of Physiology-Cell Physiology, 1995
The Na-K-Cl cotransport system of vascular endothelial cells plays a central role in maintenance and regulation of intracellular volume. Activity of the cotransporter is modulated both by hormones and by extracellular tonicity. Vasopressin and other hormones that stimulate the endothelial cotransporter act via a Ca- and calmodulin-dependent pathway ...
Martha E O'Donnell +2 more
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The Na-K-Cl cotransport system of vascular endothelial cells plays a central role in maintenance and regulation of intracellular volume. Activity of the cotransporter is modulated both by hormones and by extracellular tonicity. Vasopressin and other hormones that stimulate the endothelial cotransporter act via a Ca- and calmodulin-dependent pathway ...
Martha E O'Donnell +2 more
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Renal Na+-glucose cotransporters [PDF]
American Journal of Physiology-Renal Physiology, 2001 In humans, the kidneys filter ∼180 g of d-glucose from plasma each day, and this is normally reabsorbed in the proximal tubules. Although the mechanism of reabsorption is well understood, Na+-glucose cotransport across the brush-border membrane and facilitated diffusion across the basolateral membrane, questions remain about the identity of the genes ...
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Journal of Cellular Biochemistry, 2018
We investigated the effects of sodium‐glucose cotransporter 2 inhibitor, empagliflozin, and α‐glucosidase inhibitor, voglibose, on hepatic steatosis in an animal model of type 2 diabetes (T2DM).
Ji‐Won Kim +6 more
semanticscholar +1 more source
We investigated the effects of sodium‐glucose cotransporter 2 inhibitor, empagliflozin, and α‐glucosidase inhibitor, voglibose, on hepatic steatosis in an animal model of type 2 diabetes (T2DM).
Ji‐Won Kim +6 more
semanticscholar +1 more source
American Journal of Physiology-Cell Physiology, 1994
The Na-K-Cl cotransporters are a class of membrane proteins that transport Na, K, and Cl ions into and out of cells in an electrically neutral manner, in most cases with a stoichiometry of 1Na:1K:2Cl. Na-K-Cl cotransporters are present in a wide variety of cells and tissues, including reabsorptive and secretory epithelia, nerve and muscle cells ...
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The Na-K-Cl cotransporters are a class of membrane proteins that transport Na, K, and Cl ions into and out of cells in an electrically neutral manner, in most cases with a stoichiometry of 1Na:1K:2Cl. Na-K-Cl cotransporters are present in a wide variety of cells and tissues, including reabsorptive and secretory epithelia, nerve and muscle cells ...
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Journal of the American College of Cardiology, 2020
Thomas A. Zelniker, E. Braunwald
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Thomas A. Zelniker, E. Braunwald
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Sodium–glucose cotransporter type 2 inhibitors for the treatment of type 2 diabetes mellitus
Nature Reviews Endocrinology, 2020A. Scheen
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Comprehensive Physiology, 2018
Two genes encode the Na+ -K+ -2Cl- cotransporters, NKCC1 and NKCC2, that mediate the tightly coupled movement of 1Na+ , 1K+ , and 2Cl- across the plasma membrane of cells.
E. Delpire, K. Gagnon
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Two genes encode the Na+ -K+ -2Cl- cotransporters, NKCC1 and NKCC2, that mediate the tightly coupled movement of 1Na+ , 1K+ , and 2Cl- across the plasma membrane of cells.
E. Delpire, K. Gagnon
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Hepatology Research, 2017
No pharmacological therapies have been established for non‐alcoholic fatty liver disease (NAFLD). Sodium glucose cotransporter 2 inhibitor (SGLT2I) was developed for the treatment of adults with type 2 diabetes mellitus (T2DM).
Yuya Seko +16 more
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No pharmacological therapies have been established for non‐alcoholic fatty liver disease (NAFLD). Sodium glucose cotransporter 2 inhibitor (SGLT2I) was developed for the treatment of adults with type 2 diabetes mellitus (T2DM).
Yuya Seko +16 more
semanticscholar +1 more source
Thiazide-Sensitive NaCl Cotransporter
2015The thiazide-sensitive NaCl cotransporter (NCC, SLC12A3) is a member of the solute carrier 12 (SLC12) family of electroneutral cotransporters. NCC is expressed in the distal convoluted tubule (DCT) of the kidney, where it mediates the transport of sodium with chloride in a 1:1 stoichiometry.
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