Results 341 to 350 of about 95,583 (387)
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Current Opinion in Cell Biology, 1992
Significant advances have been made in elucidating the structure of Na+ cotransport proteins. Some fifteen of these low-abundance proteins have been cloned, sequenced and functionally expressed. They are members of the 12 membrane-spanning superfamily and they segregate into two groups, the Na+/glucose (SGLT1) and Na+/Cl-/GABA (GAT-1) families.
Karl M. Hager +2 more
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Significant advances have been made in elucidating the structure of Na+ cotransport proteins. Some fifteen of these low-abundance proteins have been cloned, sequenced and functionally expressed. They are members of the 12 membrane-spanning superfamily and they segregate into two groups, the Na+/glucose (SGLT1) and Na+/Cl-/GABA (GAT-1) families.
Karl M. Hager +2 more
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The overshoot phenomenon in cotransport
Biochimica et Biophysica Acta (BBA) - Biomembranes, 1984Based on simplified equations, the overshoot curve experimentally observed with Na+-linked cotransport of neutral substrate (sugars or amino acids) has been simulated by computer. The approach is in principle similar to that of previous approaches (Weiss, S.D., McNamara, P.D. and Segal, S. (1981) J. Theor. Biol.
Alan M. Weinstein, Erich Heinz
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Sodium–Glucose Cotransporter 2 Inhibition and Diabetic Kidney Disease
Diabetes, 2019Diabetic kidney disease (DKD) is now the principal cause of chronic kidney disease leading to end-stage kidney disease worldwide. As a primary contributor to the excess risk of all-cause and cardiovascular death in diabetes, DKD is a major contributor to
Radica Z. Alicic +4 more
semanticscholar +1 more source
Current Opinion in Cell Biology, 1990
Transport systems for low-molecular-weight solutes are generally divided into two groups: those that are driven directly by chemical reactions (e.g. ATP hydrolysis, photolysis), and those that are coupled to gradients established by the primary chemical event.
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Transport systems for low-molecular-weight solutes are generally divided into two groups: those that are driven directly by chemical reactions (e.g. ATP hydrolysis, photolysis), and those that are coupled to gradients established by the primary chemical event.
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The thermostatics and thermodynamics of cotransport
Biochimica et Biophysica Acta (BBA) - Biomembranes, 1984The thermostatics of cotransport are reviewed. A static-head equilibrium state across a cotransport system, without leaks, is thought to occur when the electrochemical potential of the driven solute, B prevents net flow of the driving solute, A. For a symport this gives the relationship (formula: see text) Where n is the stoichiometric coefficient ...
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Cotransport of phosphate and sodium by yeast
Biochimica et Biophysica Acta (BBA) - Biomembranes, 1977Phosphate uptake by yeast at pH 7.2 is mediated by two mechanisms, one of which has a Km of 30 micronM and is independent of sodium, and a sodium-dependent mechanism with a Km of 0.6 micronM, both Km values with respect to monovalent phosphate. The sodium-dependent mechanism has two sites with affinity for Na+, with affinity constants of 0.04 and 29 mM.
G.M. Roomans +2 more
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Hepatology Research, 2019
The aim of this study was to investigate the therapeutic potential of sodium glucose cotransporter 2 inhibitor (SGLT2I) as an effective therapeutic option for non‐alcoholic fatty liver disease (NAFLD).
N. Akuta +16 more
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The aim of this study was to investigate the therapeutic potential of sodium glucose cotransporter 2 inhibitor (SGLT2I) as an effective therapeutic option for non‐alcoholic fatty liver disease (NAFLD).
N. Akuta +16 more
semanticscholar +1 more source
1989
Two methods have been described for the study of cation-chloride cotransport systems. The zero-trans efflux method is designed to determine stoichiometric relationships between cotransported ions under conditions where ion exchanges cannot occur. These exchanges (e.g., Na+/Na+, K+/K+) may occur as partial or incomplete reactions of a cotransport ...
Mark Haas, Thomas J. McManus
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Two methods have been described for the study of cation-chloride cotransport systems. The zero-trans efflux method is designed to determine stoichiometric relationships between cotransported ions under conditions where ion exchanges cannot occur. These exchanges (e.g., Na+/Na+, K+/K+) may occur as partial or incomplete reactions of a cotransport ...
Mark Haas, Thomas J. McManus
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Analyzing an electrogenic cotransporter
The Journal of Membrane Biology, 1993A model for the sodium-dependent accumulation of glutamate by synaptosomes has been presented which fits the data of Wheeler and his coworkers and supports their hypothesis of an electrogenic cotransporter. Since their hypothesis was based on experimental data on the operation of the cotransporter on the outer membrane, the model was expanded to ...
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Renal sodium-phosphate cotransport
Current Opinion in Nephrology and Hypertension, 1994Proximal tubular reabsorption of inorganic phosphate (P(i) is a major determinant of the extracellular concentration of phosphate. The net proximal reabsorption of phosphate largely depends on the rate of apical sodium-dependent transport of P(i) (Na/P(i) cotransport), which is controlled by various hormonal and nonhormonal factors.
J Biber, Heini Murer
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