Results 351 to 360 of about 95,583 (387)

Random-walk model of cotransport

Physical Review E, 2020
We present a statistical mechanical model to describe the dynamics of an arbitrary cotransport system. Our starting point was the alternating access mechanism, which suggests the existence of six states for the cotransport cycle. Then we determined the 14 transition probabilities between these states, including a leak pathway, and used them to write a ...
Yan B. Barreto, Béla Suki, Adriano M. Alencar   +2 more
openaire   +3 more sources

Computational analysis of models for cotransport

Biochimica et Biophysica Acta (BBA) - Biomembranes, 1984
The order of substrate interaction with a cotransport carrier is studied by numerically fitting theoretical models to empirical data for a Na+-D-glucose pathway. Our analysis is based on a least-squares minimization routine developed at CERN, and uses data derived from tracer flux of substrate under equilibrium exchange conditions.
C.J. Lumsden, Michael Silverman, D.A. Harrison, G.W. Rowe   +3 more
openaire   +3 more sources

Sodium–glucose cotransporter inhibitors and oxidative stress: An update

Journal of Cellular Physiology, 2018
Sodium–glucose cotransporter 2 (SGLT2) inhibitors are therapeutic agents that have been used recently to reduce tubular absorption of glucose, leading to enhanced glycosuria, resulting in the reduction of blood glucose and improved diabetes control ...
Habib Yaribeygi, S. Atkin, A. Butler, A. Sahebkar   +3 more
semanticscholar   +1 more source

Molecular Mechanisms of NaCl Cotransport

Annual Review of Physiology, 1996
Electroneutral Na-(K)-Cl cotransporters are present in most cell types, where they play an important role in both sodium-chloride absorption and secretion and cell volume regulation. Recent advances in the molecular identification of these cotransporters have provided a new level of insight into the mechanisms of sodium-chloride-coupled cotransport and
M R Kaplan, D B Mount, E Delpire, G Gamba, S C Hebert   +4 more
openaire   +3 more sources

Effects of the sodium‐glucose cotransporter 2 inhibitor dapagliflozin on fluid distribution: A comparison study with furosemide and tolvaptan

Nephrology, 2019
Sodium‐glucose cotransporter 2 (SGLT2) inhibitors are an antihyperglycemic drug with diuretic properties. We recently reported that an SGLT2 inhibitor ameliorated extracellular fluid expansion with a transient increase in urinary Na+ excretion.
Ken Ohara, Takahiro Masuda, Takuya Murakami, T. Imai, Hiromichi Yoshizawa, Saki Nakagawa, M. Okada, Atsushi Miki, Akihiro Myoga, T. Sugase, Chuji Sekiguchi, Yasuharu Miyazawa, A. Maeshima, T. Akimoto, O. Saito, S. Muto, D. Nagata   +16 more
semanticscholar   +1 more source

Renal potassium-chloride cotransporters

Current Opinion in Nephrology and Hypertension, 2001
The electroneutral cotransport of potassium and chloride is mediated by potassium-chloride transporters, which are encoded by members of the gene family of cation-chloride cotransporters. A significant body of evidence argues for swelling-activated, basolateral potassium-chloride transport in the proximal tubule and thick ascending limb, with a ...
Gerardo Gamba, David B. Mount
openaire   +3 more sources

The Electroneutral Cation–Chloride Cotransporters

Journal of Experimental Biology, 1998
ABSTRACT Electroneutral cation–chloride cotransporters are widely expressed and perform a variety of physiological roles. A novel gene family of five members, encompassing a Na+–Cl− transporter, two Na+–K+–2Cl− transporters and two K+–Cl− cotransporters, encodes these membrane proteins; homologous genes have also been identified in a ...
Gerardo Gamba, R S Hoover, Eric Delpire, David B. Mount, E Poch, A E Hall, Steven C. Hebert   +6 more
openaire   +3 more sources

Regulation of Na+/Glucose Cotransporters

Journal of Experimental Biology, 1997
ABSTRACT Na+/glucose cotransporters (SGLTs) are expressed in the small intestine and the proximal renal tubule, where they play a central role in the absorption of glucose and galactose from food and the reabsorption of glucose from the glomerular filtrate.
Guido A. Zampighi, Donald D. F. Loo, J. R. Hirsch, Ernest M. Wright   +3 more
openaire   +3 more sources

Na+–sulfate cotransporter SLC13A1

Pflügers Archiv - European Journal of Physiology, 2013
Sulfate is essential for normal physiology. The kidney plays a major role in sulfate homeostasis. Sulfate is freely filtered and strongly reabsorbed in the proximal tubule. The apical membrane Na(+)-sulfate cotransporter NaS1 (SLC13A1) mediates sulfate (re)absorption across renal proximal tubule and small intestinal epithelia.
openaire   +3 more sources

Sodium‐glucose cotransporter 2 inhibitors regulate ketone body metabolism via inter‐organ crosstalk

Diabetes, obesity and metabolism, 2019
To investigate sodium‐glucose cotransporter 2 inhibitor (SGLT2i)‐induced changes in ketogenic enzymes and transporters in normal and diabetic mice models.
Jin Hee Kim, Minyoung Lee, S. H. Kim, So Ra Kim, Byung-wan Lee, E. Kang, B. Cha, J. Cho, Yong‐ho Lee   +8 more
semanticscholar   +1 more source