Results 371 to 380 of about 95,583 (387)

Na+ -K+ -2Cl- Cotransporter (NKCC) Physiological Function in Nonpolarized Cells and Transporting Epithelia.

Comprehensive Physiology, 2018
Two genes encode the Na+ -K+ -2Cl- cotransporters, NKCC1 and NKCC2, that mediate the tightly coupled movement of 1Na+ , 1K+ , and 2Cl- across the plasma membrane of cells.
E. Delpire, K. Gagnon
semanticscholar   +1 more source

Sodium-Potassium-Chloride Cotransport

Physiological Reviews, 2000
Obligatory, coupled cotransport of Na+, K+, and Cl−by cell membranes has been reported in nearly every animal cell type. This review examines the current status of our knowledge about this ion transport mechanism. Two isoforms of the Na+-K+-Cl−cotransporter (NKCC) protein (∼120–130 kDa, unglycosylated) are currently known.
openaire   +3 more sources

Sodium–glucose cotransporter type 2 inhibitors for the treatment of type 2 diabetes mellitus

Nature Reviews Endocrinology, 2020
A. Scheen
semanticscholar   +1 more source

Water transport in the brain: Role of cotransporters

Neuroscience, 2004
It is generally accepted that cotransporters transport water in addition to their normal substrates, although the precise mechanism is debated; both active and passive modes of transport have been suggested. The magnitude of the water flux mediated by cotransporters may well be significant: both the number of cotransporters per cell and the unit water ...
MacAulay, Nanna, Hamann, Steffan, Zeuthen, Thomas   +2 more
openaire   +4 more sources

Thiazide-Sensitive NaCl Cotransporter

2015
The thiazide-sensitive NaCl cotransporter (NCC, SLC12A3) is a member of the solute carrier 12 (SLC12) family of electroneutral cotransporters. NCC is expressed in the distal convoluted tubule (DCT) of the kidney, where it mediates the transport of sodium with chloride in a 1:1 stoichiometry.
openaire   +2 more sources

Effects of Sodium-Glucose Cotransporter 2 Inhibitors for the Treatment of Patients With Heart Failure: Proposal of a Novel Mechanism of Action

JAMA cardiology, 2017
M. Packer, S. Anker, J. Butler, G. Filippatos, F. Zannad   +4 more
semanticscholar   +1 more source

The cotransport systems

Current Opinion in Cell Biology, 1989
openaire   +3 more sources

Mechanisms of Na+-glucose cotransport

Biochemical Society Transactions, 1994
Mariana Panayotova-Heiermann, Kathryn J. Boorer, Ernest M. Wright, Donald D. F. Loo   +3 more
openaire   +3 more sources

The Intestinal Na+/Glucose Cotransporter

Annual Review of Physiology, 1993
openaire   +3 more sources

Structures of sodium–glucose cotransporters

Nature Reviews Nephrology, 2022
openaire   +2 more sources