Results 41 to 50 of about 62,786 (347)

Sodium-substrate cotransport in bacteria

Biochimica et Biophysica Acta (BBA) - Bioenergetics, 2001
A variety of sodium-substrate cotransport systems are known in bacteria. Sodium enters the cell down an electrochemical concentration gradient. There is obligatory coupling between the entry of the ion and the entry of substrate with a stoichiometry (in the cases studied) of 1:1.
Ping Z. Ding, T.H. Wilson
openaire   +3 more sources

Euglycemic Diabetic Ketoacidosis: A Potential Complication of Treatment With Sodium–Glucose Cotransporter 2 Inhibition

Diabetes Care, 2015
OBJECTIVE Sodium–glucose cotransporter 2 (SGLT-2) inhibitors are the most recently approved antihyperglycemic medications. We sought to describe their association with euglycemic diabetic ketoacidosis (euDKA) in hopes that it will enhance recognition of ...
A. Peters, Elizabeth O. Buschur, J. Buse, P. Cohan, Jamie C. Diner, I. Hirsch   +5 more
semanticscholar   +1 more source

Effect of tofogliflozin on cardiac and vascular endothelial function in patients with type 2 diabetes and heart diseases: A pilot study

Journal of Diabetes Investigation, 2020
Recent studies have shown that sodium–glucose cotransporter 2 inhibitors decrease the risk of heart failure in patients with type 2 diabetes. However, the precise mechanisms of action of these drugs are not well understood.
Mayu Tochiya, Hisashi Makino, Tamiko Tamanaha, Miki Matsuo, Ai Hishida, Ryo Koezuka, Yoko Ohata, Tsutomu Tomita, Choel Son, Yoshihiro Miyamoto, Satoshi Yasuda, Kiminori Hosoda   +11 more
doaj   +1 more source

Sodium Glucose Cotransporter-2 Inhibition in Heart Failure: Potential Mechanisms, Clinical Applications, and Summary of Clinical Trials

Circulation, 2017
Despite current established therapy, heart failure (HF) remains a leading cause of hospitalization and mortality worldwide. Novel therapeutic targets are therefore needed to improve the prognosis of patients with HF.
Y. Lytvyn, P. Bjornstad, J. Udell, J. Lovshin, D. Cherney   +4 more
semanticscholar   +1 more source

The electrogenic Na/HCO3 cotransporter

Kidney International, 1989
Cet article de synthese fait le point sur les systemes de transport du bicarbonate dans les cellules animales; (epithelium du rein et de la cornee et dans les cellules non epitheliales; cellules musculaires et nerveuses). Description des echangeurs Cl-HCO 3 dependants et independants du sodium. Sensibilite aux inhibiteurs. Stœchiometrie.
Walter F. Boron, Emile L. Boulpaep
openaire   +3 more sources

Favorable effect of sodium–glucose cotransporter 2 inhibitor, dapagliflozin, on non‐alcoholic fatty liver disease compared with pioglitazone

Journal of Diabetes Investigation, 2020
Sodium–glucose cotransporter 2 inhibitors, as well as thiazolidines, suppress nonalcoholic fatty liver disease (NAFLD); however, few comparative studies have been reported.
K. Cho, A. Nakamura, Kazuno Omori, T. Takase, A. Miya, Kohei Yamamoto, H. Nomoto, H. Kameda, S. Taneda, Y. Kurihara, S. Aoki, T. Atsumi, H. Miyoshi   +12 more
semanticscholar   +1 more source

Efficacy of Sodium-Glucose Cotransporter 2 Inhibitors in Heart Failure with a Preserved Ejection Fraction: A Meta-Analysis of Randomized Controlled Trials

Reviews in Cardiovascular Medicine, 2022
Background: Heart failure is prevalent worldwide. Sodium-glucose cotransporter 2 inhibitors (SGLT2i) are effective in heart failure patients with reduced ejection fraction, whether SGLT2i are effective in heart failure with preserved ejection fraction ...
Yake Lou, Qi Yang, Weicong Zhang, Ying Yu, Jing Huang   +4 more
doaj   +1 more source

Heart Failure Risk Stratification and Efficacy of Sodium-Glucose Cotransporter-2 Inhibitors in Patients With Type 2 Diabetes Mellitus.

Circulation, 2019
Patients with type 2 diabetes mellitus (T2DM) are at increased risk of developing heart failure. Sodium-glucose cotransporter-2 inhibitors reduce the risk of hospitalization for heart failure (HHF) in patients with T2DM.
D. Berg, S. Wiviott, B. Scirica, Yared Gurmu, Ofri Mosenzon, S. Murphy, Deepak L. Bhatt, Lawrence A Leiter, Darren K Mcguire, John P H Wilding, P. Johanson, P. Johansson, A. Langkilde, I. Raz, E. Braunwald, M. Sabatine   +15 more
semanticscholar   +1 more source

The Cerebrospinal Fluid Secretion Rate Increases in Awake and Freely Moving Rats but Differs With Experimental Methodology

Advanced Science, EarlyView.
CSF dynamics are vital for neurological health. Yet accurate quantification of CSF rates is challenging. Using a novel technique in awake, freely moving rats, significantly higher secretion rates are found than in anesthetized rats. The findings highlight the importance of awake models and the adaptability of methods for studying CSF changes influenced
Trine L. Toft‐Bertelsen, Beatriche L. Edelbo, Annette B. Steffensen, Sara D. Lolansen, Jonathan H. Wardman, Dennis B. Jensen, Nanna MacAulay   +6 more
wiley   +1 more source

Cotransporter-mediated water transport underlying cerebrospinal fluid formation

Nature Communications, 2018
Cerebrospinal fluid (CSF) production occurs at a rate of 500 ml per day in the adult human. Conventional osmotic forces do not suffice to support such production rate and the molecular mechanisms underlying this fluid production remain elusive.
A. B. Steffensen, E. K. Oernbo, Anca Stoica, Niklas J. Gerkau, Dagne Barbuskaite, K. Tritsaris, C. Rose, N. MacAulay   +7 more
semanticscholar   +1 more source