Results 51 to 60 of about 95,583 (387)

The SGLT2 inhibitor empagliflozin for the treatment of type 2 diabetes mellitus: A bench to bedside review [PDF]

, 2014
INTRODUCTION: The treatment of type 2 diabetes mellitus (T2DM) continues to pose challenges for clinicians and patients. The dramatic rise in T2DM prevalence, which has paralleled the rise in obesity, has strained the healthcare system and prompted the ...
McGill, Janet B
core   +2 more sources

Heart Failure Risk Stratification and Efficacy of Sodium-Glucose Cotransporter-2 Inhibitors in Patients With Type 2 Diabetes Mellitus.

Circulation, 2019
Patients with type 2 diabetes mellitus (T2DM) are at increased risk of developing heart failure. Sodium-glucose cotransporter-2 inhibitors reduce the risk of hospitalization for heart failure (HHF) in patients with T2DM.
D. Berg, S. Wiviott, B. Scirica, Yared Gurmu, Ofri Mosenzon, S. Murphy, Deepak L. Bhatt, Lawrence A Leiter, Darren K Mcguire, John P H Wilding, P. Johanson, P. Johansson, A. Langkilde, I. Raz, E. Braunwald, M. Sabatine   +15 more
semanticscholar   +1 more source

Structure of the human cation–chloride cotransporter NKCC1 determined by single-particle electron cryo-microscopy

Nature Communications, 2020
The secondary active cation–chloride cotransporters (CCCs) utilize the existing Na+ and/or K+ gradients to move Cl− into or out of cells. NKCC1 is an intensively studied member of the CCC family and plays fundamental roles in regulating trans-epithelial ...
Xiaoyong Yang, Qinzhe Wang, E. Cao
semanticscholar   +1 more source

Bilirubin Targeting WNK1 to Alleviate NLRP3‐Mediated Neuroinflammation

Advanced Science, EarlyView.
At physiological concentrations, bilirubin binds to the kinase domain of WNK1, thereby augmenting its activity and facilitating the phosphorylation of downstream SPAK/OSR1. This phosphorylation inhibits KCC2 activity, leading to elevate intracellular chloride levels in neurons.
Linfei Mao, Jiayu Lu, Quanjun Yang, Zhenqi Liu, Cuiping Wu, Bingbing Ke, Kaiyan Su, Haolin Yuan, Yaqi Cui, Yao Wang, Richard Salvi, Guang Yang, Shankai Yin, Feng Liu, Chunyan Li   +14 more
wiley   +1 more source

Efficacy of Sodium-Glucose Cotransporter 2 Inhibitors in Heart Failure with a Preserved Ejection Fraction: A Meta-Analysis of Randomized Controlled Trials

Reviews in Cardiovascular Medicine, 2022
Background: Heart failure is prevalent worldwide. Sodium-glucose cotransporter 2 inhibitors (SGLT2i) are effective in heart failure patients with reduced ejection fraction, whether SGLT2i are effective in heart failure with preserved ejection fraction ...
Yake Lou, Qi Yang, Weicong Zhang, Ying Yu, Jing Huang   +4 more
doaj   +1 more source

Sodium‐glucose cotransporter 1 as a sugar taste sensor in mouse tongue

Acta Physiologica, 2020
We investigated potential neuron types that code sugar information and how sodium‐glucose cotransporters (SGLTs) and T1Rs are involved.
K. Yasumatsu, T. Ohkuri, R. Yoshida, Shusuke Iwata, R. Margolskee, Y. Ninomiya   +5 more
semanticscholar   +1 more source

Presbycusis: Pathology, Signal Pathways, and Therapeutic Strategy

Advanced Science, EarlyView.
In ARHL, the stria vascularis, acting as a cochlear battery, gradually loses its ability to maintain the endocochlear potential, leading to impaired hair cell function and progressive hearing loss. Single‐cell sequencing reveals age‐related cellular changes in the cochlea, providing insights into the underlying mechanisms of aging and potential ...
Xiaoxu Zhao, Tian Shen, Shengda Cao, Ziyi Liu, Wendu Pang, Meixuan Li, Jingjing Liu, Wen Li, Yunhao Wu, Chengcheng Liu, Ming Xia, Xiaolong Fu, Cheng Cheng   +12 more
wiley   +1 more source

Sodium-glucose cotransporter-1 inhibition and depression: A Mendelian randomization study

SAGE Open Medicine
Objective: The present study aims to determine the causal association between sodium-glucose cotransporter inhibitors and depression, as previous observational studies have concluded a potential link between sodium-glucose cotransporter 1/2 inhibition ...
Gang Fan, Hong Zuo, Xun Shi, Bo Liu
doaj   +1 more source

The effect of modern hypoglycemic therapy on the course of chronic kidney disease in patients with type 2 diabetes mellitus

Mìžnarodnij Endokrinologìčnij Žurnal, 2021
The article presents the literature review of the possibilities of modern antidiabetic therapy in the prevention of chronic kidney disease in patients with type 2 diabetes mellitus.
V.I. Katerenchuk
doaj   +1 more source

Single‐Cell RNA Sequencing Delineates Renal Anti‐Fibrotic Mechanisms Mediated by TRPC6 Inhibition

Advanced Science, EarlyView.
Single‐cell transcriptomics reveals how TRPC6 inhibition alters renal cell composition and gene expression in CKD. The study uncovers a novel endothelial subpopulation (ECRIN), highlights key inflammatory and fibrotic pathways, and identifies a Prnp‐driven network linked to fibrosis resolution, offering mechanistic insight into TRPC6 as a potential ...
Yao Xu, Zhihuang Zheng, Marleen Silke Oswald, Guozhe Cheng, Jun Liu, Qidi Zhai, Ute Kruegel, Michael Schaefer, Holger Gerhardt, Nicole Endlich, Maik Gollasch, Stefan Simm, Dmitry Tsvetkov   +12 more
wiley   +1 more source