Results 61 to 70 of about 62,786 (347)
British Journal of Clinical Pharmacology, EarlyView.Aims The aim of this phase 1 trial was to assess the pharmacokinetics, safety and tolerability of balcinrenone (previously AZD9977) in participants with severe renal impairment vs. those with normal renal function. Methods Participants with severe renal impairment (estimated glomerular filtration rate [eGFR] < 30 mL/min/1.73 m2) not on dialysis were ...
Chandrali S. Bhattacharya +10 more
wiley +1 more source
Sodium-Glucose Cotransporter-2 Inhibitors in Diabetic Patients with Heart Failure: An Update
PharmaceuticalsDiabetes mellitus and heart failure are two diseases that are commonly found together, in particular in older patients. High blood glucose has a detrimental effect on the cardiovascular system, and worse glycemic control contributes to the onset and the ...
Nicia I. Profili +5 more
doaj +1 more source
PLoS ONE, 2017 Cation Chloride Cotransporters (CCCs) comprise secondary active membrane proteins mainly mediating the symport of cations (Na+, K+) coupled with chloride (Cl-). They are divided into K+-Cl- outward transporters (KCCs), the Na+-K+-Cl- (NKCCs) and Na+-Cl- (
Anna-Maria Hartmann +3 more
doaj +1 more source
Cardiovascular Outcomes and Risks After Initiation of a Sodium Glucose Cotransporter 2 Inhibitor
Circulation, 2018 Background: Clinical trials have shown cardiovascular benefits and potential risks from sodium glucose cotransporter 2 inhibitors (SGLT2i). Trials may have limited ability to address individual end points or safety concerns.
J. Udell +5 more
semanticscholar +1 more source
Dynamic Imaging of the Sodium Phosphate Cotransporters [PDF]
Advances in Chronic Kidney Disease, 2011 Although in vivo and cell culture studies have provided useful information about the regulation of the sodium phosphate (NaPi) cotransporters, such studies are unable to provide information at the molecular level about interactions between proteins. The NaPi proteins are found within both intestinal and renal brush border microvilli, and previous work ...
JUDITH BLAINE +7 more
openaire +5 more sources
European Journal of Heart Failure, Volume 24, Issue 11, Page 2131-2139, November 2022., 2022 Among patients with new‐onset or worsening heart failure (HF) undergoing optimization of HF medical therapy, dose up‐titration of angiotensin‐converting enzyme inhibitor/angiotensin receptor blocker (ACEi/ARB) therapy was associated with lower likelihood of left atrial adverse remodelling (LAAR).
Riccardo M. Inciardi +16 more
wiley +1 more source
Stochastic models of cotransport
, 2023 Cell membrane transport plays a pivotal role in facilitating communication between the cell and its environment. Within this context, cotransport emerges as a vital mechanism, harnessing electrochemical gradients to energize the transmembrane translocation of solutes.
openaire +1 more source
Real Time Hemodynamic Monitoring During M‐TEER Using Electrical Cardiometry
Catheterization and Cardiovascular Interventions, EarlyView.ABSTRACT Background Mitral regurgitation is a common valvular dysfunction causing patient morbidity and mortality. Mitral transcatheter edge‐to‐edge repair (M‐TEER) allows grasping of valvular leaflets and approximation via a small implant, thus reducing mitral regurgitation (MR).
Andreas Goldschmied +6 more
wiley +1 more source
European Journal of Heart Failure, Volume 24, Issue 11, Page 2152-2161, November 2022., 2022 Triple guideline‐directed medical therapy (GDMT) prescription was associated with a lower 2‐year mortality compared to non‐triple GDMT prescription (A). Such association was observed in patients with concomitant comorbidities (B). CI, confidence interval; CKD, chronic kidney disease; CMP, cardiomyopathy; HR, hazard ratio; MRA, mineralocorticoid ...
Satoshi Higuchi +36 more
wiley +1 more source
Cryo-EM structures of the human cation-chloride cotransporter KCC1
Science, 2019 Coupled transport Cation-chloride cotransporters move chloride and cations across the cell membrane and are important in regulating cell volume and setting the chloride concentration inside the cell.
Si Liu +12 more
semanticscholar +1 more source