Results 61 to 70 of about 95,583 (387)

Metabolic response to sodium-glucose cotransporter 2 inhibition in type 2 diabetic patients.

Journal of Clinical Investigation, 2014
BACKGROUND Sodium-glucose cotransporter 2 (SGLT2) inhibitors lower glycemia by enhancing urinary glucose excretion. The physiologic response to pharmacologically induced acute or chronic glycosuria has not been investigated in human diabetes.
E. Ferrannini, E. Muscelli, S. Frascerra, S. Baldi, A. Mari, T. Heise, U. Broedl, H. Woerle   +7 more
semanticscholar   +1 more source

Physiology of renal glucose handling via SGLT1, SGLT2 and GLUT2. [PDF]

, 2018
The concentration of glucose in plasma is held within narrow limits (4-10 mmol/l), primarily to ensure fuel supply to the brain. Kidneys play a role in glucose homeostasis in the body by ensuring that glucose is not lost in the urine.
Ghezzi, Chiara, Loo, Donald DF, Wright, Ernest M   +2 more
core  

Na+-dependent D-mannose transport at the apical membrane of rat small intestine and kidney cortex [PDF]

, 2001
The presence of a Na+/D-mannose cotransport activity in brush-border membrane vesicles (BBMV), isolated from either rat small intestine or rat kidney cortex, is examined.
Calonge Castrillo, María Luisa, Cano Rodríguez, María Mercedes, Durán Martínez, Juan Manuel, García Delgado, Marta, Horra Padilla, Carmen de la, Ilundáin Larrañeta, María Anunciación Ana, Peral Rubio, María José   +6 more
core   +1 more source

The sodium phosphate cotransporter family SLC34 [PDF]

Pfl�gers Archiv European Journal of Physiology, 2004
This review summarizes the characteristics of the solute carrier family SLC34 that is represented by the type ll Na/P(i)-cotransporters NaPi-lla (SLC34A1), NaPi-llb (SLC34A2) and NaPi-llc (SLC34A3). Other Na/P(i)-cotransporters are described within the SLC17 and SLC20 families.
Murer, H, Forster, I C, Biber, J
openaire   +5 more sources

A Human Engineered Heart Tissue‐Derived Lipotoxic Diabetic Cardiomyopathy Model Revealed Early Benefits of Empagliflozin

Advanced Science, EarlyView.
This study develops a human engineered heart tissue‐derived model of diabetic cardiomyopathy that accurately replicates the dynamic changes in the structural, contractile, and electrophysiological properties of the myocardium. Furthermore, this model is used to confirm the direct protective effects of empagliflozin on the heart through an SGLT2 off ...
Lin Cai, Yuxin Zhao, Zilong Li, Liping Xiao, Yifan Wu, Shiya Wang, Qian Liu, Yida Ye, Yuxuan Guo, Donghui Zhang   +9 more
wiley   +1 more source

The Na+/Glucose Cotransporter Inhibitor Canagliflozin Activates AMPK by Inhibiting Mitochondrial Function and Increasing Cellular AMP Levels

Diabetes, 2016
Canagliflozin, dapagliflozin, and empagliflozin, all recently approved for treatment of type 2 diabetes, were derived from the natural product phlorizin. They reduce hyperglycemia by inhibiting glucose reuptake by sodium/glucose cotransporter (SGLT) 2 in
S. Hawley, R. Ford, Brennan K Smith, Graeme J. Gowans, S. Mancini, Ryan D. Pitt, Emily A. Day, Ian P Salt, Gregory R. Steinberg, D. G. Hardie   +9 more
semanticscholar   +1 more source

Influx of Calcium through L-type Calcium Channels in Early Postnatal Regulation of Chloride Transporters in the Rat Hippocampus [PDF]

, 2009
During the early postnatal period, GABAB receptor activation facilitates L-type calcium current in rat hippocampus. One developmental process that L-type current may regulate is the change in expression of the K+Cl− co-transporter (KCC2) and N+K+2Cl− co ...
Balakrishnan, Ben-Ari, Ben-Ari, Bettler, Bi, Blaesse, Carter, Cherubini, Davies, Delpire, Dutar, Fiumelli, Fujikawa, Galanopoulou, Ganguly, Gähwiler, Harrison, Hübner, Kahle, Kanaka, Kanaumi, Khazipov, Lambert, Leinekugel, Leinekugel, Leinekugel, Liu, Lu, Mynlieff, Newberry, Nuñez, Owens, Payne, Pfrieger, Plotkin, Rissman, Rivera, Scholz, Shen, Siebler, Stein, Takahashi, Thompson, Vicario-Abejón, Wang, Wu, Yan, Yu, Yuste   +48 more
core   +2 more sources

Extracellular Vesicles in Calcium Oxalate Nephrolithiasis: Emerging Biomarkers and Therapeutic Potential

Advanced NanoBiomed Research, EarlyView.
Kidney stones cause significant pain and healthcare costs. Current prediction, diagnosis, and treatment options are limited. Extracellular vesicles (EVs), rich in proteins, lipids, and nucleic acids, offer a promising solution. This review explores the roles of EVs in kidney stone management, highlighting their potential as biomarkers and therapeutic ...
Wang Zhu, Xu Changzhi, Deng Qiong, Liang Hui   +3 more
wiley   +1 more source

Cardioprotective effects of sodium glucose cotransporter 2 inhibitor versus dipeptidyl peptidase 4 inhibitor in type 2 diabetes: A meta-analysis of comparative safety and efficacy

SAGE Open Medicine
Background: Sodium glucose cotransporter 2 inhibitors are recommended for the treatment of heart failure due to their cardioprotective effects, despite primarily being used as antidiabetic medications. However, the comparative profile of two antidiabetic
Abhigan Babu Shrestha, Anupam Halder, Kripa Rajak, Saroj Kumar Jha, Ramesh Lamichhane, Arefin Naher Oishee, Nayanika Tummala Chowdary, Pashupati Pokharel, Sajina Shrestha, Lukash Adhikari, Bikash Adhikari, Aman Rajak, Jalal Haider Khan, Nischal Mainali   +13 more
doaj   +1 more source

Constraints of FL Motif on the Targeting and Function of Sodium-Bicarbonate Cotransporter 1 [PDF]

, 2008
A C-terminal dihydrophobic FL motif plays a vital role in the basolateral targeting of sodium bicarbonate cotransporter 1. To further characterize the role of dihydrophobic FL motif, 1). the FL motif in wild type (PFLS) was reversed to LF (PLFS), 2). the
Ali Shawki, Bryan Mackenzie, Emily Y Li, Hong C. Li, Joel H. Collier, Kyung-Soo Hahm, Manoocher Soleimani, YoonKyung Park   +7 more
core   +1 more source