Results 81 to 90 of about 95,583 (387)

Adaptive changes in GFR, tubular morphology, and transport in subtotal nephrectomized kidneys: modeling and analysis [PDF]

, 2017
Removal of renal mass stimulates anatomical and functional adaptations in the surviving nephrons, including elevations in single-nephron glomerular filtration rate (SNGFR) and tubular hypertrophy. A goal of this study is to assess the extent to which the
Edwards, Aurelie, Layton, Anita T., Vallon, Volker   +2 more
core   +1 more source

Structural Pharmacology of Cation-Chloride Cotransporters

Membranes, 2022
Loop and thiazide diuretics have been cornerstones of clinical management of hypertension and fluid overload conditions for more than five decades. The hunt for their molecular targets led to the discovery of cation-chloride cotransporters (CCCs) that catalyze electroneutral movement of Cl− together with Na+ and/or K+.
Yongxiang Zhao, Erhu Cao
openaire   +3 more sources

An Euroheart‐Based Percutaneous Coronary Intervention Registry in Vietnam: Design, Rationale, and Preliminary Results

Catheterization and Cardiovascular Interventions, EarlyView.
ABSTRACT Background As a cardiac interventional procedure, percutaneous coronary intervention (PCI) is increasingly becoming the most widely adopted across the globe. With increasing implementation in practice, the use of PCI registries to evaluate safety and effectiveness has grown internationally.
Vu Hoang Vu, Khang Duong Nguyen, Bao Thien Duong, Ngoc Minh Pham, Christopher M. Reid, Binh Quang Truong, Richard Norman   +6 more
wiley   +1 more source

Stochastic models of cotransport

, 2023
Cell membrane transport plays a pivotal role in facilitating communication between the cell and its environment. Within this context, cotransport emerges as a vital mechanism, harnessing electrochemical gradients to energize the transmembrane translocation of solutes.
openaire   +1 more source

Impact of Model‐Informed Drug Development on Drug Development Cycle Times and Clinical Trial Cost

Clinical Pharmacology &Therapeutics, EarlyView.
Model‐informed drug development (MIDD) integrates data to quantify benefit/risk informing objective drug discovery and development decisions. An additional critical benefit of MIDD is postulated to be improvement in trial and program efficiencies. While the application of MIDD has grown, there have been no clear examples across programs to demonstrate ...
Vaishali Sahasrabudhe, Timothy Nicholas, Gianluca Nucci, Cynthia J Musante, Brian Corrigan   +4 more
wiley   +1 more source

Empagliflozin is associated with improvements in liver enzymes potentially consistent with reductions in liver fat: results from randomised trials including the EMPA-REG OUTCOME® trial [PDF]

, 2018
Aims/hypothesis: In addition to beneficial effects on glycaemia and cardiovascular death, empagliflozin improves adiposity indices. We investigated the effect of empagliflozin on aminotransferases (correlates of liver fat) in individuals with type 2 ...
Fitchett, David, George, Jyothis T., Hantel, Stefan, Sattar, Naveed, Zinman, Bernard   +4 more
core   +1 more source

Cation-Chloride Cotransporters and Neuronal Function [PDF]

Neuron, 2009
Recent years have witnessed a steep increase in studies on the diverse roles of neuronal cation-chloride cotransporters (CCCs). The versatility of CCC gene transcription, posttranslational modification, and trafficking are on par with what is known about ion channels.
Kai Kaila, Matti S. Airaksinen, Peter Blaesse, Claudio Rivera   +3 more
openaire   +3 more sources

Embryonic cerebrospinal fluid pressure in fetal mice in utero: External factors pressurize the intraventricular space

Developmental Dynamics, EarlyView.
Abstract Background Previous experiments inducing leakage of embryonic cerebrospinal fluid (CSF) suggest the necessity of intraventricular CSF pressure (PCSF) for brain morphogenesis. Nevertheless, how embryonic PCSF occurs is unclear, especially in utero. Results Using a Landis water manometer, we measured PCSF in fetal mice isolated from the amniotic
Koichiro Tsujikawa, Reina Muramatsu, Takaki Miyata   +2 more
wiley   +1 more source

Euglycemic diabetes ketoacidosis associated with SGLT-2 inhibitors - review of case reports

Journal of Education, Health and Sport
AIM: Sodium-glucose cotransporter 2 (SGLT-2) inhibitors have gained significant importance in the treatment of type 2 diabetes mellitus. One of the adverse effects while using SGLT-2 inhibitors is euglycemic ketoacidosis (euDKA) - acute life-threatening ...
Joanna Winciorek, Piotr Cyran, Anna Jaroszyńska, Filip Jaroszyński, Joanna Kowal, Jan Paleczny, Robert Parobczak, Paweł Jakub Połujański, Adrianna Marta Wiśniewska   +8 more
doaj   +1 more source

Case report of superior mesenteric artery syndrome that developed in a lean type 2 diabetes patient and was associated with rapid body weight loss after sodium–glucose cotransporter 2 inhibitor administration

Journal of Diabetes Investigation, 2020
A 58‐year‐old women who was diagnosed with type 2 diabetes 20 years earlier had been treated with antidiabetic medicines since she was aged 40 years. After sodium–glucose cotransporter 2 inhibitors administration, her bodyweight rapidly decreased from 40
Taro Hirai, Munehiro Kitada, Yoshihiro Hayashi, Itaru Monno, Yuta Takagaki, Keiji Shimada, Yoshio Ogura, Mizue Fujii, Kazunori Konishi, Atsushi Nakagawa, Daisuke Koya   +10 more
doaj   +1 more source