Results 81 to 90 of about 62,786 (347)

Wavelet analysis of corneal endothelial electrical potential difference reveals cyclic operation of the secretory mechanism [PDF]

arXiv, 2011
There is evidence that the electrical potential difference of corneal endothelium (TEPD) is related electro-osmotically to fluid transport. Hence, determination of the TEPD would serve as a measure of the fluid movement. The oscillatory nature of the TEPD has been recognized recently using the Fourier transform; the oscillations of the highest ...
arxiv  

Cation-Chloride Cotransporters and Neuronal Function [PDF]

Neuron, 2009
Recent years have witnessed a steep increase in studies on the diverse roles of neuronal cation-chloride cotransporters (CCCs). The versatility of CCC gene transcription, posttranslational modification, and trafficking are on par with what is known about ion channels.
Kai Kaila, Matti S. Airaksinen, Peter Blaesse, Claudio Rivera   +3 more
openaire   +3 more sources

A novel mouse model of heatstroke accounting for ambient temperature and relative humidity

Journal of Intensive Care, 2021
Background Heatstroke is associated with exposure to high ambient temperature (AT) and relative humidity (RH), and an increased risk of organ damage or death. Previously proposed animal models of heatstroke disregard the impact of RH. Therefore, we aimed
Kazuyuki Miyamoto, Keisuke Suzuki, Hirokazu Ohtaki, Motoyasu Nakamura, Hiroki Yamaga, Masaharu Yagi, Kazuho Honda, Munetaka Hayashi, Kenji Dohi   +8 more
doaj   +1 more source

Iodide Binding in Sodium-Coupled Cotransporters [PDF]

Journal of Chemical Information and Modeling, 2017
Several apical iodide translocation pathways have been proposed for iodide efflux out of thyroid follicular cells, including a pathway mediated by the sodium-coupled monocarboxylate transporter 1 (SMCT1), which remains controversial. Herein, we evaluate structural and functional similarities between SMCT1 and the well-studied sodium-iodide symporter ...
Ariela Vergara-Jaque, Peying Fong, Jeffrey Comer   +2 more
openaire   +3 more sources

The sodium/glucose cotransport family SLC5 [PDF]

Pfl�gers Archiv European Journal of Physiology, 2004
The sodium/glucose cotransporter family (SLCA5) has 220 or more members in animal and bacterial cells. There are 11 human genes expressed in tissues ranging from epithelia to the central nervous system. The functions of nine have been revealed by studies using heterologous expression systems: six are tightly coupled plasma membrane Na(+)/substrate ...
Ernest M. Wright, Eric Turk
openaire   +3 more sources

Implementation of guideline‐directed medical therapy in patients with heart failure with reduced ejection fraction (OpTIMa‐HF Registry)

ESC Heart Failure, EarlyView.
Abstract Aims The last released European guidelines on the management of heart failure (HF) recommend in patients with chronic HF with reduced ejection fraction (HFrEF) a pharmacological approach based on four fundamental drugs to be rapidly implemented and then uptitrated to modify disease progression.
Stefania Paolillo, Christian Basile, Federica Marzano, Dario Bruzzese, Piergiuseppe Agostoni, Irene Mattavelli, Angelo Aloisio, Pietro Ameri, Martina Solimano, Natale Daniele Brunetti, Paolo Calabrò, Arturo Cesaro, Matteo Cameli, Giulia Elena Mandoli, Erberto Carluccio, Chiara Belardinelli, Stefano Carugo, Laura Casalino, Emilia Chiuini, Deborah Cosmi, Frank Lloyd Dini, Mariafrancesca Di Santo, Gennaro Esposito, Ferdinando Ferrara, Maria Francesca Fierro, Gennaro Galasso, Luca Gallo, Antonella Rispoli, Paola Gargiulo, Francesco Grigioni, Andrea Segreti, Franco Guarnaccia, Natale Guarnaccia, Federico Guerra, Emanuele Cicchirillo, Ciro Indolfi, Mauro Larcher, Adele Lillo, Marco Metra, Roberta Montisci, Maria Francesca Marchetti, Savina Nodari, Francesco Fioretti, Ermanno Nardi, Ugo Oliviero, Alberto Palazzuoli, Giuseppe Patti, Marco Pepe, Filomena Pacelli, Fabrizio Perrone Filardi, Giuseppe Putortì, Giosuè Santoro, Michele Senni, Emilia D'Elia, Paolo Severino, Andrea D'Amato, Simona Soriano, Gianfranco Sinagra, Maddalena Rossi, Monica Franzese, Giovanni Smaldone, Giovanni Battista Zito, Pasquale Perrone Filardi   +62 more
wiley   +1 more source

Ipragliflozin, a sodium–glucose cotransporter 2 inhibitor, reduces bodyweight and fat mass, but not muscle mass, in Japanese type 2 diabetes patients treated with insulin: A randomized clinical trial

Journal of Diabetes Investigation, 2019
Sodium–glucose cotransporter 2 inhibitors reduce bodyweight (BW) by creating a negative energy balance. Previous reports have suggested that this BW reduction is mainly loss of body fat and that ~20% of the reduction is lean mass. However, the effects of
Hideka Inoue, K. Morino, S. Ugi, S. Tanaka-Mizuno, Keiko Fuse, I. Miyazawa, Keiko Kondo, Daisuke Sato, Natsuko Ohashi, Shogo Ida, Osamu Sekine, M. Yoshimura, K. Murata, K. Miura, H. Arima, H. Maegawa   +15 more
semanticscholar   +1 more source

Investigation of left ventricular ejection fraction in a Swiss heart failure population: Insights into mortality and sex differences

ESC Heart Failure, EarlyView.
Graphical representation of main findings and article highlights. Abstract Aims Understanding heart failure (HF) characteristics is essential to improve patient outcomes. Categorizing HF beyond left ventricular ejection fraction (LVEF) is challenging due to heterogeneous clinical presentation and aetiologies.
Rubén Fuentes Artiles, Renald Meçani, Taulant Muka, Lukas Hunziker, Lukas Capék   +4 more
wiley   +1 more source

KCC2-Mediated Cl− Extrusion Modulates Spontaneous Hippocampal Network Events in Perinatal Rats and Mice

Cell Reports, 2019
Summary: It is generally thought that hippocampal neurons of perinatal rats and mice lack transport-functional K-Cl cotransporter KCC2, and that Cl− regulation is dominated by Cl− uptake via the Na-K-2Cl cotransporter NKCC1. Here, we demonstrate a robust
Inkeri Spoljaric, Albert Spoljaric, Martina Mavrovic, Patricia Seja, Martin Puskarjov, Kai Kaila   +5 more
doaj  

Sodium–glucose cotransporters: Functional properties and pharmaceutical potential

Journal of Diabetes Investigation, 2020
Glucose is the most abundant monosaccharide, and an essential source of energy for most living cells. Glucose transport across the cell membrane is mediated by two types of transporters: facilitative glucose transporters (gene name: solute carrier 2A ...
Ryuhei Sano, Yuichi Shinozaki, Takeshi Ohta   +2 more
doaj   +1 more source