The Wonders of Vanilla: Celebrating the 150th Anniversary of Synthetic Vanillin
The year 2024 marked the 150th anniversary of the first commercial production of vanillin, one of the world's most cherished flavor ingredients. This review traces vanilla's history from Mesoamerica to modern production methods, examines its composition, the discovery of vanillin and Haarmann's early synthesis compared to modern methods, and highlights
Elisabetta Brenna +2 more
wiley +1 more source
Bioactive Phenolic Acid Derivatives and Undescribed Esculetin Glycosides from <i>Pseudopodospermum szowitzii</i> (DC.) Kuth. [PDF]
Sarıaltın SY +3 more
europepmc +1 more source
Cinnamon (Cinnamomum spp.) is used as a culinary spice and dietary supplement. A major constituent, cinnamaldehyde, was previously shown to inactivate cytochrome P450 (CYP) 2A6 in vitro. A mechanistic static model predicted an ~5‐fold increase in the AUC of the CYP2A6 substrates nicotine and letrozole.
Aiden‐Hung P. Nguyen +8 more
wiley +1 more source
Total Synthesis of Kayeassamin A and Mammeasin A: Overcoming Challenges in the Construction of Sterically Overcrowded Pentasubstituted Coumarin Frameworks. [PDF]
Takashima K +9 more
europepmc +1 more source
ABSTRACT Objectives To systematically review and meta‐analyze the impact of fluorescent versus conventional orthodontic adhesives on debonding efficiency, bond strength, and enamel integrity. Methods This systematic review and meta‐analysis, following the PRISMA guidelines, searched PubMed, Scopus, Embase, Web of Science, and Cochrane Central ...
Maryam Omidkhoda +3 more
wiley +1 more source
Torsion-Induced π-Conjugation Offers an Approach to Small Coumarin-Based Color-Changing Fluorescent Sensors of Esterase Activity. [PDF]
Oronova A +3 more
europepmc +1 more source
Mechanisms of Gui Zhi Fu Ling Formula in Liver Fibrosis: Metabolomics and Gut Microbiota Analysis
Our study was based on the efficacy of the phenotype in an animal model and used multi‐omics to explore the mechanism of action of the compound. We found that Gui Zhi Fu Ling Formula may ameliorate hepatic fibrosis potentially associated with increased hepatic EPA and the expression of gut Pseudomonas.
Xiaoliang Deng +5 more
wiley +1 more source
Potent and selective α-glucosidase inhibition by coumarin-triazole conjugates: design, <i>in vivo</i> evaluation, and computational insights. [PDF]
Sadeghi Moghadam M +11 more
europepmc +1 more source
The review critically evaluated and compared the selected superfruit phytochemistry, their bioactive composition and the key health benefits majorly emphasizing the antioxidant potential. It has highlighted the translational challenges in formulating functional foods by addressing the issues related to delivery system, bioavailability mechanism and the
Sharath Kumar Nagaraja +3 more
wiley +1 more source
Plasma metabolomic signatures in children with autism spectrum disorder and their modulation following a gluten-free modified ketogenic diet. [PDF]
Singh R +4 more
europepmc +1 more source

