Results 71 to 80 of about 43,230 (246)

Fluorescent Diarylethenes With Polar Groups: Synthesis, Spectra, and Optical Microscopy Applications

Chemistry – A European Journal, EarlyView.
Blinking green and flashing red: photo‐switchable and photo‐activatable probes emitting green and red light were prepared and applied as bioconjugates in super‐resolution optical microscopy. ABSTRACT The use of photoactivatable fluorescent diarylethenes (fDAEs) in biology‐related light microscopy has been restricted by the lack of probes having freely ...
Kakishi Uno, Sven Nagorny, Ayse Aktalay, Dojin Kim, Mariano L. Bossi, Vladimir N. Belov, Stefan W. Hell   +6 more
wiley   +1 more source

Late‐Stage Phenylation From [13C6] and [2H5]Benzene: A Versatile Tool for Stable Isotope Labeled MS Standards

Chemistry – A European Journal, EarlyView.
ABSTRACT We explored aryl thianthrenation as a tool for directly incorporating multiple isotopes into molecular scaffolds starting from full isotopically labeled benzene. Stable isotope‐labeled (SIL) molecules are indispensable tools for investigating chemical and biological mechanisms and quantifying metabolites.
Alexandre Labiche, Bouchaib Mouhsine, Dorian Dupommier, Louise Fogel, Frédéric Robert, David‐Alexandre Buisson, Frédéric Taran, Davide Audisio   +7 more
wiley   +1 more source

Coumarin derivatives as inhibitors against monoamine oxidase: structure-activity relationships and inhibitory mechanisms

Acta Materia Medica
Monoamine oxidase (MAO) is a useful target in the treatment of neurodegenerative diseases and depressive disorders. Understanding the structure-activity relationship (SAR) and mechanisms underlying MAO inhibitors is crucial but challenging.
Jie Sun, Leizhi Xu, Qiusha Pan, Pu Wang, Qingguang Zhang, Ping Wang, Yangliu Xia   +6 more
doaj   +1 more source

Synthetic Strategies for Activity‐Based Probes to Decode Ubiquitin‐Like Modifiers

Chemistry – A European Journal, EarlyView.
ABSTRACT Ubiquitin‐like proteins (Ubls) such as SUMO, NEDD8, ISG15, URM1, UFM1, FAT10, ATG8/ATG12, and FUBI are essential regulators of cellular homeostasis, controlling processes from protein stability and trafficking to immune signaling and autophagy.
Saibal Chanda, Alan Pham, SreeNidhi Karnati, Natalia Soto Rodriguez, Alyssa Toner, Wenshe Ray Liu   +5 more
wiley   +1 more source

Copper‐ and Silver‐Catalyzed Reactions of Active Methylene Isocyanides: Facile Access to Highly Substituted Five‐ and Six‐Membered Heterocycles

Chemistry – A European Journal, EarlyView.
This review summarizes recent advances in copper‐ and silver‐catalyzed reactions of active methylene isocyanides for the synthesis of highly substituted five‐ and six‐membered heterocycles. Emphasis is placed on [3+n] cycloadditions, annulations, and asymmetric strategies, highlighting current limitations and future opportunities in heterocycle ...
Jimil George, Kyungsoo Oh
wiley   +1 more source

Study of Zn(II)-coumarin complex by electrochemical method with increased anticoagulant potency

Reviews in Analytical Chemistry, 2011
The formation of complexes of coumarin and Zn(II) was studied in aqueous media at pH 8.2±0.1 by polarography and spectroscopy. The polarogram indicated formation of complexes between coumarin and Zn(II).
Choure Rakesh, Vaidya Neelam, Pitre Krishna Sadashiv   +2 more
doaj   +1 more source

Pharmacokinetic Evaluation of a Cinnamon Product on CYP2A6 Substrate Drugs: Application of a Novel Tool Involving the Nicotine Metabolite Ratio

Clinical Pharmacology &Therapeutics, EarlyView.
Cinnamon (Cinnamomum spp.) is used as a culinary spice and dietary supplement. A major constituent, cinnamaldehyde, was previously shown to inactivate cytochrome P450 (CYP) 2A6 in vitro. A mechanistic static model predicted an ~5‐fold increase in the AUC of the CYP2A6 substrates nicotine and letrozole.
Aiden‐Hung P. Nguyen, Deena L. Hadi, Daniel A. Todd, Preston K. Manwill, John R. White, Matthew E. Layton, Nadja B. Cech, Kenneth E. Thummel, Mary F. Paine   +8 more
wiley   +1 more source

Boosting Water Vapor‐Assisted Methane Photooxidation Over S‐Scheme MIL‐125‐NH2(Ti)/WO3 Heterojunction Photocatalysts

EcoEnergy, EarlyView.
The MIL‐125‐NH2(Ti)/WO3‐x S‐scheme heterostructure was constructed via electrostatic self‐assembly, strategically aligning energy bands to optimize interfacial charge transfer and ·OH generation for C–H activation. The optimized MW‐3 demonstrates exceptional CH4 photooxidation activity using water vapor as a sustainable oxidant, achieving a remarkable ...
Jia‐Min Cao, Jing Ren, Ya‐Ting Zheng, Ya‐Nan Wang, Ye Wang, Wen‐Wen Dong, Jun Zhao, Dong‐Sheng Li, Zhi‐Ming Zhang   +8 more
wiley   +1 more source

Molten Zinc Coordination Polymer Glass as a Host for Stable and Processable Optical Dye Composites

EcoEnergy, EarlyView.
Zinc‐based coordination polymer glass is employed to suppress aggregation‐caused quenching (ACQ) and enhance molecular stability, enabling improved luminescence performance in the solid state. The emission color of the hybrid composites can be tuned by varying the incorporated guest molecules, while the glass matrix effectively prevents aggregation and
Jaeho Lee, Wengang Huang, Yoshiki Sugai, Xiangyi Zha, Yuelei Chen, Joshua A. Powell, Yi‐Chen Hsu, Zixi Xie, Vicki Chen, Lianzhou Wang, Jingwei Hou   +10 more
wiley   +1 more source

MELD score predicts outcomes in patients with advanced heart failure: A longitudinal evaluation

ESC Heart Failure, Volume 12, Issue 2, Page 839-847, April 2025.
Abstract Aims Advanced heart failure (AHF) is characterized by recurrent episodes of haemodynamic instability and frequent hospitalizations, leading to a progressive decline in quality of life and high mortality rates. The objectives of this study were to evaluate the effect of the model for end‐stage liver disease (MELD) score and its variations in ...
Francesco Curcio, Cristiano Amarelli, Rosaria Chiappetti, Irene Mattucci, Veronica Flocco, Mahmoud Issa Rammal, Ciro Abete, Francesca Mazzella, Ciro Maiello, Pasquale Abete, Francesco Cacciatore   +10 more
wiley   +1 more source