Results 101 to 110 of about 827,585 (306)

Mass spectrometry based identification of AMP‐O‐Tris generated by Thermococcus onnurineus Cas10

open access: yesFEBS Open Bio, EarlyView.
Isolated Thermococcus onnurineus Cas10 generates the noncanonical ATP‐derived product AMP‐O‐Tris while in Tris‐containing buffer as identified via mass spectrometry, revealing relaxed nucleophile selectivity under isolated conditions. These findings suggest that multiprotein Csm complex assembly restricts Cas10 reactivity toward canonical cyclic ...
Su‐Jin Lee   +6 more
wiley   +1 more source

Refinement of amino‐acid conformation vs. difference density maps in time‐resolved serial femtosecond crystallography data analysis

open access: yesFEBS Open Bio, EarlyView.
The dFoCC pipeline starts with observed DED and resting‐state coordinates, which are then used to generate a library of triggered states. Correlation analysis of the calculated DED features of each candidate vs observed DED permits quantitative evaluation of candidate structural quality.
Meng Iao Fong   +3 more
wiley   +1 more source

The Administrative Judge and European Convention guaranteed rights for Human Rights Protection

open access: yesZbornik Radova Pravnog Fakulteta u Splitu, 2012
In the historical development of the French administrative judge several moments in time have been differentiated. The first period was from 1947-1989 where court decisions were very rarely based on Convention provisions.
Jean Massot
doaj  

Economic Council of Mongolia: on the 100th Anniversary of its Establishment

open access: yesМонголоведение
Introduction. 2024 marks the 100th anniversary of the founding of the Economic Council of Mongolia, the formation of which as part of the Ministry of Finance was adopted at a meeting of the People’s Government on November 18, 1924.
Keemya V. Orlova
doaj   +1 more source

Acute caffeine treatment protects the developing retina from ischemia‐induced cell death

open access: yesFEBS Open Bio, EarlyView.
Caffeine reduces cell death in the developing retina under ischemia (OGD). This effect does not involve BDNF upregulation or antioxidant pathways (NRF2/VEGF). Neuroprotection occurs mainly through adenosine A2A receptor antagonism, decreasing glutamate release and excitotoxicity, highlighting caffeine's potential as an acute neuroprotective agent in ...
Amanda Alves Nascimento   +6 more
wiley   +1 more source

Supervision of the Appeal Judge in Administrative Dispute

open access: yesZbornik Radova Pravnog Fakulteta u Splitu, 2014
Up to 1950 the State legal advisor was the only judicial body of general supervision for administrative disputes. Today, since their foundation in 1953, administrative courts are first instance judicial bodies in administrative disputes.
Marc Gjidara
doaj  

Other title: September Council meeting : progress report

open access: yes, 1947
"September 1947."SEPTEMBER COUNCIL MEETING -- Status of Council Work -- New Proposals Introduced -- COMMITTEE ACTIVITY AND REPORTS -- Agriculture and Livestock -- Assessment and Taxation -- Proposal 5, Tax-Exempt Government Property -- Proposal 8 ...
Kansas. Legislature. Legislative Council.
core  

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

open access: yesFEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero   +5 more
wiley   +1 more source

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