Results 91 to 100 of about 443,997 (287)

Erken Dönem Hıristiyan Teolojisinde Meryem

Dinler Tarihi
Meryem, Hıristiyanlıkta teslis inancından sonra en çok bahse konu edilen figür olarak karşımıza çıkmaktadır. Bugün Hıristiyanların ibadet hayatında da manevi hayatlarında da önemli bir yer tutan Meryem’in adeta bir tanrıça konumuna sahip olduğu ...
Rumeysa Çiçek
doaj  

Incompleteness: Remarks on Arendt's Method

Azafea: Revista de Filosofía
Hannah Arendt is commonly criticized for defining action as an end in itself, of horizontal power and of councils as an alternative to representative democracy that is unrealistic and unrealizable.
Wolfgang Heuer
doaj   +1 more source

Aerobic capacity and hematological response to exercise: A study on school-going regularly exercising boys in two different air pollution zones

Journal of Exercise Science & Fitness, 2015
Background/Objective: The purpose of this study was to evaluate the effects of exercise on aerobic power and hematological profile among trained school-going boys in an environment with similar climatic characteristics but different concentrations of air
Paulomi Das, Pinaki Chatterjee
doaj   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Next‐generation proteomics improves lung cancer risk prediction

Molecular Oncology, EarlyView.
This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj, Clara Frick, Ben Schöttker, Bernd Holleczek, Hermann Brenner   +4 more
wiley   +1 more source

Gestão participativa e política de patrimônio no Município de Belo Horizonte: realidade ou mito?

Ciências Sociais Unisinos, 2005
This article analyzes the protection of buildings considered as cultural patrimony in the city of Belo Horizonte, state of Minas Gerais, on the basis of the actions undertaken by the Deliberative Council for Cultural Patrimony of the Municipality of Belo
Nilo Lima de Azevedo, Tarcísio Rodrigues Botelho   +1 more
doaj  

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

A subset of MMR‐proficient colon cancers responds to neoadjuvant immunotherapy

Molecular Oncology, EarlyView.
Tan et al. reveal that a distinct subset of early‐stage pMMR colon cancers can respond to neoadjuvant immunotherapy. In the NICHE‐2 trial, responders (26%) were characterized by chromosomal instability, TP53 mutations, and proliferative cell‐cycle programs, whereas nonresponders showed metabolic and stromal reprogramming with TGF‐β‐driven ...
Eleonora Piumatti, Giovanni Germano, Pietro Paolo Vitiello, Alberto Bardelli   +3 more
wiley   +1 more source

The quality of district plans and their implementation: Towards environmental quality [PDF]

, 2002
Since inception of the Resource Management Act 1991 (RMA) the issue of sustainable management has dominated planning practice in New Zealand. Over the past decade, councils have wrestled with converting the concept of sustainable management into policy
Backhurst, Michael, Berke, Philip, Chapman, Sarah, Crawford, Janet, Day, Maxine, Dixon, Jennifer, Ericksen, Neil, Laurian, Lucie   +7 more
core   +1 more source

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

Molecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg, Joachim von Braun, Julio Celis, Anton Berns, Michael Baumann, Tit Albreht, Nancy Abou‐Zeid, Vanderlei Bagnato, Christian Brandts, Chien‐Jen Chen, Massimiliano di Pietro, Manjit Dosanjh, Thomas Dubois, Alexander Eggermont, Angelika Eggert, Ingemar Ernberg, Sara Faithfull, Johannes Förner, Stefan Fröhling, Manuel Heitor, Leroy Hood, Wei Jiang, Bengt Jönsson, Ravi Kannan, Maria Leptin, Su Li, Peter Lindgren, Douglas Lowy, Jun Ma, Alex Markham, Péter Nagy, Simon Oberst, M. Iqbal Parker, Danielle Rodin, Kevin Ryan, Joachim Schüz, Richard Sullivan, Josep Tabernero, Peter Turkson, Oliver Várhelyi, Harold Varmus, Chijie Wang, Elisabete Weiderpass, Nils Wilking   +43 more
wiley   +1 more source