Results 61 to 70 of about 448,314 (304)
The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity
Molecular Oncology, EarlyView.Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli +7 more
wiley +1 more source
“On the participation of Laity in the affairs of the Church, from the perspective of Orthodox canon law”: Speech by A. S. Pavlov at the meeting of Kazan University on November 5, 1866. Preparation of the text for publication, introductory article by M. A. Naumova [PDF]
Вестник Свято-Филаретовского институтаReaders are kindly offered an abridged version of the speech delivered on 5 November 1866 at a meeting of Kazan University by A. S. Pavlov, associate professor of Canon Law (later distinguished professor of the Department of Ecclesiastical Law at the ...
Marina A. Naumova
doaj +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Health Science ReportsBackground and Aim There is still limited evidence on the relationships between strategic planning practices and strategic results in the health sector. The study aimed to examine and quantify these relationships in Tanzania.
Mwandu Kini Jiyenze +2 more
doaj +1 more source
The Person and the Challenges, 2018 This article analyses the evolution of the goods of the Church and its administration dur - ing the first millennium of the Christian era. It reveals the first community of Jerusalem where believers had everything in common, discusses the centrality ...
Jorge Antonio Di Nicco
doaj +1 more source
Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma
Molecular Oncology, EarlyView.Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra +6 more
wiley +1 more source
Using wage council data to identify the effect of recessions on the impact of the minimum wage [PDF]
, 2011 Up until now the National Minimum Wage (NMW) introduced in April 1999 appears to have been a policy success. So far there has been little evidence of a negative effect on employment.
Dickens, Richard, Dolton, Peter
core
The evolution of political ideas of zemstvo’s workers and employees (June 1917 – June 1918) [PDF]
Известия Саратовского университета. Новая серия: История. Международные отношенияBased on the analysis of publications of departmental journals “Zemsky Delo” and “Zemsky Worker”, the author of the article tried to reconstruct several stages of development of political ideas of zemstvo’s workers and ...
Sobornov, Pavel E.
doaj +1 more source
Efficiency of Organizations Entitled to Award Academic Degrees
Интеграция образования, 2020 Introduction. As part of the Bologna process since September 1, 2016, the Russian government has granted the right to award academic degrees to leading educational and scientific organizations on par with Dissertation Defense Councils under Higher ...
Sergey I. Pakhomov +4 more
doaj +1 more source
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source