Results 61 to 70 of about 1,804,421 (390)

The anti‐CRISPR protein AcrIE8.1 inhibits the type I‐E CRISPR‐Cas system by directly binding to the Cascade subunit Cas11

open access: yesFEBS Letters, EarlyView.
In this study, we present the structure of AcrIE8.1, a previously uncharacterized anti‐CRISPR protein that inhibits the type I‐E CRISPR‐Cas system. Through a combination of structural and biochemical analyses, we demonstrate that AcrIE8.1 directly binds to the Cas11 subunit of the Cascade complex to inhibit the CRISPR‐Cas system.
Young Woo Kang, Hyun Ho Park
wiley   +1 more source

The Current Status of School Counseling Outcome Research [PDF]

open access: yes, 2005
Wendy McGannon has taken the lead in developing a review and analysis of The Current Status of School Counseling Outcome Research. Some basic information related to the NCLB mandates are reviewed in terms of how they impact the school counseling ...
Carey, Jay   +2 more
core   +1 more source

Why emerging leaders should focus on being good postdoctoral supervisors

open access: yesFEBS Letters, EarlyView.
Swamped with work and suddenly a new student is waiting at your doorstep for supervision? Great—this is your chance! In this article, we share tips on how postdocs can strengthen their leadership skills while supervising students. This image has been created using DALL·E. Many postdocs work as leaders later in their career.
Hannah Rostalski   +5 more
wiley   +1 more source

Comparing Personality Dimensions and coping Strategies in Healthy Individuals and Heart Patients

open access: yesMajallah-i Dānishgāh-i ’Ulūm-i Pizishkī-i Shahīd Ṣadūqī Yazd, 2016
Introduction: Heart disease is a psycho-physiological disorder that in addition to physical and biological factors, psychological factors such as stressful events, personality traits and coping strategies play an important role in its occurrence and ...
R Rahimi, M Arefi, M Golmohammadian
doaj  

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

open access: yesFEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang   +9 more
wiley   +1 more source

Effectiveness of Solution- Focused Brief Therapy (SFBT) on Reducing Depression and Increasing Marital Satisfaction in Married Women

open access: yesنشریه پرستاری ایران, 2017
Background & Aim: Solution- focused brief therapy is among modern approaches in individual, couple and family therapies which focus on finding solutions rather than on problems.
A Abbasi   +4 more
doaj  

EFFECT OF BALANCE COUNSELING STRATEGY TOWARDS KNOWLEDGE AND ATTITUDE IN CONTRACEPTION AMONG PREGNANT WOMEN

open access: yesIndonesian Midwifery and Health Sciences Journal, 2021
Background: The use of postpartum contraception is ideally used after delivery under 42 days. Data obtained from the BKKBN of East Java Province, the achievement of unmet need in Surabaya is 13.31% of the unmet need target of 10.44%.
Alfi Syifa Darmastuti   +3 more
doaj   +1 more source

Ethnolinguistic concordance and the receipt of postpartum IUD counseling services in Sri Lanka. [PDF]

open access: yes, 2018
CONTEXT: Ethnic and linguistic concordance are important dimensions of the patient-physician relationship, and are linked to health care disparities.
Canning, David   +5 more
core   +1 more source

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

open access: yesFEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

open access: yesFEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe   +3 more
wiley   +1 more source

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