Results 161 to 170 of about 279,737 (286)

Expected costs and benefits of genetic counselling and germline genetic testing in metastatic prostate cancer. [PDF]

Hum Genet
Vlaming M, Kiemeney LALM, Koole W, van Oort IM, Bleiker EMA, Ausems MGEM, Frederix GWJ.   +6 more
europepmc   +1 more source

Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids

FEBS Open Bio, EarlyView.
Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão, Diogo M. Engrácia, Graça Soveral, Filipa Mendes   +3 more
wiley   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

'<i>I am now confident in the counseling and in inserting the loop':</i> assessing the feasibility of providing hormonal intrauterine devices at the primary health care level in Tanzania. [PDF]

Glob Health Action
Kikula A, Ngowi J, Porter Erlank C, Muhumba T, Mvunabandi S, Mbuguni Z, Naphtali G, Mtumbuka E, Ruhago G, Sunguya B, Pembe AB.   +10 more
europepmc   +1 more source

Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1

FEBS Open Bio, EarlyView.
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay, Junjie Xu, Josep Rizo   +2 more
wiley   +1 more source

A Pilot Randomised Controlled Trial of a Targeted Dietary Approach to Potassium Management in Hemodialysis: A Clinical Research Protocol for the Evidence for Optimal Potassium Intake in Hemodialysis (EvoKe-HD) Study. [PDF]

Can J Kidney Health Dis
Bernier-Jean A, Goupil R, Madore F, Dawson J, Papineau R, Jaure A, Clase C.   +6 more
europepmc   +1 more source

Small RNA pathways in mammalian oocytes

FEBS Open Bio, EarlyView.
Three distinct small RNA pathways operate in mammalian oocytes: RNAi interference (RNAi), the microRNA (miRNA) pathway, and the PIWI‐associated RNA (piRNA) pathway. These pathways use small RNAs to guide sequence‐specific repression and contribute to oocyte biology by targeting genes and mobile elements or appear insignificant since different ...
Petr Svoboda, Josef Pasulka
wiley   +1 more source

Quitline Counsellors' Experiences With Vaping and Nicotine Replacement Therapy for Smoking Cessation in Australian Drug and Alcohol Services. [PDF]

Drug Alcohol Rev
Rich JL, Segan CJ, Trigg J, Guillaumier A, Moore L, Manning V, Dunlop A, Garfield JBB, Daglish M, Walker N, Bullen C, Baird D, Lubman D, Gartner C, Baker A, Bonevski B.   +15 more
europepmc   +1 more source

Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA

FEBS Open Bio, EarlyView.
PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro, Fernando Lucas Palhano   +1 more
wiley   +1 more source

Circle of care model for strengthening newborn care through Kangaroo Mother Care integration in primary health systems in rural India. [PDF]

BMJ Paediatr Open
Thakral Y, Gulechha A, Mohan SB, Mohan P.   +3 more
europepmc   +1 more source