Results 201 to 210 of about 154,788 (266)

Lifestyle intervention to reduce cardiovascular risk in kidney transplant recipients: the KT-LIFESTYLE multicentre randomized controlled trial. [PDF]

Clin Kidney J
Totti V, Tabanelli G, Stecchi M, Brodosi L, Grandinetti V, Pizzuti V, D'Intino PE, Ferrarini D, Capelli E, Di Michele R, Mosconi G, Albertazzi V, Cordella E, Brigidi P, Morelli MC, La Manna G, Tarantino G.   +16 more
europepmc   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Gestational Diabetes in Somali Women: Neglected Risks for Maternal and Neonatal Health. [PDF]

Int J Womens Health
Mudei NM, Adawe MMM, Ali HA, Mohamud KH.
europepmc   +1 more source

Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1

FEBS Open Bio, EarlyView.
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay, Junjie Xu, Josep Rizo   +2 more
wiley   +1 more source

Primary healthcare practitioners' views and experiences of providing postpartum contraception counselling and care: a rapid review. [PDF]

Fam Pract
Perkins J, Stuckey S, Mazza D, Botfield JR.   +3 more
europepmc   +1 more source

Small RNA pathways in mammalian oocytes

FEBS Open Bio, EarlyView.
Three distinct small RNA pathways operate in mammalian oocytes: RNAi interference (RNAi), the microRNA (miRNA) pathway, and the PIWI‐associated RNA (piRNA) pathway. These pathways use small RNAs to guide sequence‐specific repression and contribute to oocyte biology by targeting genes and mobile elements or appear insignificant since different ...
Petr Svoboda, Josef Pasulka
wiley   +1 more source

Intensive Dietary and Activity Counselling (IDAC) study: a randomised trial following infants genetically susceptible to type 1 diabetes to prevent β-cell dysfunction and islet autoimmunity - a study protocol. [PDF]

BMJ Open
Aronsson CA, Hummel S, Eriksson Hallström E, Gudmundsson T, Maziarz M, Elding Larsson H.   +5 more
europepmc   +1 more source

Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA

FEBS Open Bio, EarlyView.
PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro, Fernando Lucas Palhano   +1 more
wiley   +1 more source

Dietitians' views on the advantages and limitations of online dietary counselling for adults in Malaysia: a qualitative study. [PDF]

BMJ Open
Cheah KJ, Razalli NH, Mat Ludin AF, Abdul Manaf Z.   +3 more
europepmc   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source