Results 51 to 60 of about 546,250 (288)
FEBS Letters, EarlyView.Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi +5 more
wiley +1 more source
BMC PsychologyBackground Parental mental health is a critical determinant of family functioning and child development. Many parents experience heightened vulnerability to stress, depression, and anxiety during the transition to parenthood and across different stages ...
Sibel Maral +2 more
doaj +1 more source
Organoids in pediatric cancer research
FEBS Letters, EarlyView.Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley +1 more source
Setting the scene: Why research matters [PDF]
, 2014 This chapter introduces the current field of research in counselling and psychotherapy. It first takes a historical perspective in describing the strong move in British psychotherapy and counselling towards ‘evidence-based’ practice.
Cooper, Mick +2 more
core
Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10
FEBS Letters, EarlyView.Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang +8 more
wiley +1 more source
The early years of innovative approaches to youth information and counselling [PDF]
, 2012 This chapter focuses on the innovative services set up for the specific purpose of giving social support to young people by means of information and counselling in youth information and counselling services.
Faché, Willy
core +1 more source
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Evaluation of the Welsh School-based Counselling Strategy : Final Report [PDF]
, 2011 The Welsh Government's School-based Counselling Strategy (the Strategy), implemented from April 2008 in secondary schools across Wales and a pilot selection of primary schools, was evaluated.
Cooper, Mick +5 more
core
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
A pilot study for the preliminary validation of the Negative Emotions Scale (NES)
Discover PsychologyThe classification of emotional distress has significant diagnostic and treatment implications in psychological therapy. Traditionally models of distress have favoured a unitary model of emotions where an emotional reaction is dysfunctional according to ...
Dominic L. O’Farrell +2 more
doaj +1 more source