Results 81 to 90 of about 546,250 (288)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Systematic literature review of career sustainability informing social cognitive career theory for SDG related skills in higher education

Discover Sustainability
Background Globalization, technological disruption, and sustainability challenges have intensified the need for higher education to ensure career sustainability and long-term success.
Hendra Pribadi, Adi Atmoko, Imanuel Hitipeuw, Henny Indreswari, Palasara Brahmani Laras, Fiki Prayogi   +5 more
doaj   +1 more source

Adolescents’ perceptions of safety in cyberbullying: the role of bystander support and relationship dynamics

International Journal of Adolescence and Youth
The present study examines the perceptions of 90 adolescents aged 13-17 (Mage = 14.42, SD = 1.33, 55 female) on positive and negative forms of bystander support.
Sara-Zoe Civita, Larbi Benallal, Karissa Leduc, Victoria Talwar   +3 more
doaj   +1 more source

Feasibility Study on Establishing a Genetic Resources Fund [PDF]

, 2001
Report on the findings of a feasibility and planning study on establishing a genetic resources fund, prepared by Community Counseling Services Ltd. The fund would be used to upgrade and endow the genetic resource collections of the CGIAR Centers and to ...
Community Counselling Service Ltd.
core  

Whose future? Whose choosing?: Counselling in a context of (im)possible choice. [PDF]

, 2011
Critically reflexive practice is at the heart of counselling, and even more so when clients come face to face with (im)possible choices. As counsellor educators, the authors show counselling practice at the edge of uncertainty.
Crocket, Kathie, Kotzé, Elmarie
core   +2 more sources

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Uptake of home-based voluntary HIV testing in sub-Saharan Africa: a systematic review and meta-analysis [PDF]

, 2012
Improving access to HIV testing is a key priority in scaling up HIV treatment and prevention services. Home-based voluntary counselling and testing (HBT) as an approach to delivering wide-scale HIV testing is explored ...
AM Molesworth, AT Choko, B Wolff, C Michelo, DF Stroup, E Lugada, E Tumwesigye, EJ Mills, EL Corbett, F Nuwaha, F Obare, FG Felley, G Rucker, H Maheswaran, I Ganguli, J Negin, J Wachira, JK Matovu, JK Matovu, JK Matovu, JM Turan, JN Sekandi, K Kranzer, Kalpana Sabapathy, KL Grabbe, KM De Cock, M Freeman, M May, M Sweat, N Angotti, N Menzies, Nathan Ford, O Shisana, P Braitstein, P Cherutich, P Macpherson, R Hayes, Rafael Van den Bergh, RC Vreeman, Richard Hayes, RM Granich, RP Walensky, S Helleringer, S Kimaiyo, Sarah Fidler, Stephanie L. Sansom, T Welz, V Ochieng-Ooko, W Mutale, W Were, WA Were   +50 more
core   +4 more sources

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

The Scientist-Practitioner in a Counselling Psychology Setting [PDF]

, 2006
The human psyche is influenced by an extraordinary complexity of experiences. Many would therefore maintain that we can never completely understand another human being.
Bury, D., Strauss, S. M.
core  

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source