Results 91 to 100 of about 26,597,943 (299)
, 2021 Presentation at the 17th RDA Plenary Meeting RDA/WDS Scholarly Link Exchange (Scholix): Promoting Data Citation Adoption via ...
openaire +1 more source
Digestive Diseases and Sciences, 2017 BackgroundMachine learning tools identify patients with blood counts indicating greater likelihood of colorectal cancer and warranting colonoscopy referral.AimsTo validate a machine learning colorectal cancer detection model on a US community-based ...
M. Hornbrook +6 more
semanticscholar +1 more source
Extended Poisson–Tweedie: Properties and regression models for count data [PDF]
, 2016 We propose a new class of discrete generalized linear models based on the class of Poisson–Tweedie factorial dispersion models with variance of the form μ + ϕ μ p , where μ is the mean and ϕ and p are the dispersion and Tweedie power parameters ...
W. H. Bonat +4 more
semanticscholar +1 more source
Cell wall target fragment discovery using a low‐cost, minimal fragment library
FEBS Letters, EarlyView.LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source
How to normalize metatranscriptomic count data for differential expression analysis
bioRxiv, 2017 BACKGROUND Differential expression analysis on the basis of RNA-Seq count data has become a standard tool in transcriptomics. Several studies have shown that prior normalization of the data is crucial for a reliable detection of transcriptional ...
Heiner Klingenberg, P. Meinicke
semanticscholar +1 more source
FEBS Letters, EarlyView.Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson +7 more
wiley +1 more source
Structural biology of ferritin nanocages
FEBS Letters, EarlyView.Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley +1 more source
Flexible Regression Models for Count Data Based on Renewal Processes: The Countr Package
Journal of Statistical Software, 2019 A new alternative to the standard Poisson regression model for count data is suggested. This new family of models is based on discrete distributions derived from renewal processes, i.e., distributions of the number of events by some time t.
Tarak Kharrat +3 more
doaj +1 more source
Count data in biology—Data transformation or model reformation?
Ecology and Evolution, 2018 Statistical analyses are an integral component of scientific research, and for decades, biologists have applied transformations to data to meet the normal error assumptions for F and t tests.
A. St-Pierre +2 more
semanticscholar +1 more source
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source