Results 81 to 90 of about 26,597,943 (299)

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Determinants of MNE Activity in Poland: The Case of Firms from EU-15

Entrepreneurial Business and Economics Review, 2017
Objective: The main purpose of this paper is to validate empirically the theoretical predictions of the modified knowledge capital model of multinational enterprise and identify the main reasons for undertaking international production in Poland by ...
Andrzej Cieślik
doaj   +1 more source

Visualizing Count Data Regressions Using Rootograms [PDF]

, 2016
The rootogram is a graphical tool associated with the work of J. W. Tukey that was originally used for assessing goodness of fit of univariate distributions. Here, we extend the rootogram to regression models and show that this is particularly useful for
Christian Kleiber, A. Zeileis
semanticscholar   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

The zero inflated negative binomial – Crack distribution: some properties and parameter estimation [PDF]

Songklanakarin Journal of Science and Technology (SJST), 2015
The zero inflated negative binomial-Crack (ZINB-CR) distribution is a mixture of Bernoulli distribution and negative binomial-Crack (NB-CR) distribution, which is an alternative distribution for the excessive zero counts and overdispersion.
Pornpop Saengthong, Winai Bodhisuwan, Ampai Thongteeraparp   +2 more
doaj  

Spatial patterns and determinants of fertility levels among women of childbearing age in Nigeria

South African Family Practice, 2017
Background: Despite aggressive measures to control the population in Nigeria, the population of Nigeria still remains worrisome. Increased birth rates have significantly contributed to Nigeria being referred to as the most populous country in Africa ...
Oluwayemisi O Alaba, Olusanya E Olubusoye, J O Olaomi   +2 more
doaj   +1 more source

Measures of clustering and heterogeneity in multilevel Poisson regression analyses of rates/count data

Statistics in Medicine, 2017
Multilevel data occur frequently in many research areas like health services research and epidemiology. A suitable way to analyze such data is through the use of multilevel regression models.
P. Austin, H. Stryhn, G. Leckie, J. Merlo   +3 more
semanticscholar   +1 more source

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source