Results 51 to 60 of about 45,936 (263)
Molecular Oncology, EarlyView.We established the avian chorioallantoic membrane (CAM) assay as a scalable in vivo model for studying circulating tumor cells (CTCs). Human gastrointestinal tumors spontaneously released genetically validated CTCs that were detected across multiple platforms, demonstrating that the CAM model provides an accessible tool for investigating early cancer ...
Dennis Roth +17 more
wiley +1 more source
Heat transfer enhancement of a channel flow by rotation circular cylinder
Nihon Kikai Gakkai ronbunshu, 2015 Heat transfer measurement has been done for a low speed water channel with an insertion of rotation circular cylinder in order to find an effective way to achieve high heat transfer enhancement by dynamic flow control method.
Norihiro TAKAHASHI +5 more
doaj +1 more source
Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation
Molecular Oncology, EarlyView.How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim +11 more
wiley +1 more source
Transient rotation of photospheric vector magnetic fields associated with a solar flare
Nature Communications, 2018 The violent solar eruptions known as flares are caused by magnetic reconnection. Here, the authors identify a sudden 12°–20° counter clockwise rotation of vector magnetic fields in photosphere, associated with the emissions of moving flare ribbons.
Yan Xu +9 more
doaj +1 more source
Substrate Effect on Catalytic Loop and Global Dynamics of Triosephosphate Isomerase
Entropy, 2013 The opening/closure of the catalytic loop 6 over the active site in apo triosephosphate isomerase (TIM) has been previously shown to be driven by the global motions of the enzyme, specifically the counter-clockwise rotation of the subunits. In this work,
Pemra Doruker, Zeynep Kurkcuoglu
doaj +1 more source
On the dynamics of thin shells of counter-rotating particles [PDF]
Classical and Quantum Gravity, 2009 23 pages, 5 figures,
Gleiser, Reinaldo J., Ramirez, Marcos A.
openaire +2 more sources
FEBS Open Bio, EarlyView.In this study, a novel esterase from the thermoacidophilic archaeon Thermoplasma acidophilum was biochemically and structurally characterized. Our results demonstrate that Ta0887 is a highly thermostable esterase that preferentially hydrolyzes p‐nitrophenyl hexanoate and possesses an α‐helical cap domain that likely contributes to its substrate ...
Alejandro Delgado‐Rey +4 more
wiley +1 more source
FEBS Open Bio, EarlyView.Human ABCE1 cannot functionally replace its yeast ortholog. Yeast–human chimera analysis identified NBD1 as a major interspecies barrier. Genetic screening yielded hABCE1 revertants that rescue yeast viability but fail to suppress aberrant translation reinitiation in the 3′ UTR.
Eriko Nakata +3 more
wiley +1 more source
Deep Learning Pose Estimation for Phenotyping of Co‐Occurring Hyperkinetic Movement Disorders
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective To explore whether routine outpatient video combined with deep learning‐based pose estimation and clinically interpretable kinematic features can support multi‐label phenotyping of co‐occurring hyperkinetic movement disorders (HMDs).
Laura Cif +17 more
wiley +1 more source
Numerical Flow Analysis in a Rotating Square Duct and a Rotating Curved-Duct
International Journal of Rotating Machinery, 2000 A numerical study is conducted on the fully-developed laminar flow of an incompressible viscous fluid in a square duct rotating about a perpendicular axis to the axial direction of the duct. At the straight duct, the rotation produces vortices due to the
Je Hyun Baekt, Chang Hwan Ko
doaj +1 more source