Results 91 to 100 of about 856,429 (315)
The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes
FEBS Letters, EarlyView.Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga +3 more
wiley +1 more source
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
Frontiers in Psychology, 2019 Human beings are supposed to possess an approximate number system (ANS) dedicated to extracting and representing approximate numerical magnitude information as well as an object tracking system (OTS) for the rapid and accurate enumeration of small sets ...
Jan Lonnemann +15 more
doaj +1 more source
FEBS Letters, EarlyView.Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure +3 more
wiley +1 more source
Accounting and Materialism in the History of Ideas
Jurnal Akuntansi Multiparadigma, 2012 Current popular culture is connected to the birth of a secular and materialistic interpretation of reality. Materialism, which is the tendency to be more concerned with material values through rational experimentation and discourse.
Ratnam Alagiah
doaj
Children’s Early Understanding of the Successor Function
Journal of Numerical CognitionChildren learn the cardinalities of the first numbers one, two, three and four before they learn how counting tracks cardinality for all numbers. It may be that when children start to understand counting, they also discover how numbers relate to one ...
Theresa Elise Wege +2 more
doaj +1 more source
Evidence for a Mixed Timing and Counting Strategy in Mice Performing a Mechner Counting Task
Frontiers in Behavioral Neuroscience, 2019 Numerosity, or the ability to understand and distinguish between discrete quantities, was first formalized for study in animals by Mechner (1958a). Rats had to press one lever (the counting lever) n times to arm food release from pressing a second lever (
Kenneth R. Light +7 more
doaj +1 more source
Journal of Computer and System Sciences, 1992 zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Shlomo Moran +2 more
openaire +1 more source
FEBS Letters, EarlyView.Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai +4 more
wiley +1 more source