Results 101 to 110 of about 856,429 (315)

Compact-eight channel photon counting module with monolithic array detector

, 2007
We present a multichannel photon counting module that exploits a monolithic array of single-photon avalanche diodes (SPADs). The detector array consists of eight 50μm diameter SPADs featuring low dark counting rate and high photon detection efficiency ...
MARANGONI, STEFANO, RECH, IVAN, M. Ghioni, COVA, SERGIO, D. Resnati, S. Marangoni, RESNATI, DANIELE, GHIONI, MASSIMO ANTONIO, S. Cova, I. Rech   +9 more
core   +1 more source

(Necessarily) Finite Lexis

Studies in Logic, Grammar and Rhetoric
This short work sets out to argue that the set of simple expressions comprising the lexicon of a given individual and the lexis of a given community are not just contingently but necessarily finite at any given moment in time.
Lemanek Kamil
doaj   +1 more source

Ubiquitination of secretory granules promotes their crinophagic degradation in Drosophila

FEBS Letters, EarlyView.
Ubiquitination of secretory granules in Drosophila larval salivary glands is a critical molecular trigger for crinophagy, the lysosomal degradation of unreleased, or low‐quality granules. The E3 ubiquitin ligase Cnot4 is recruited to the surface of secretory granules to induce crinophagy.
Tamás Csizmadia, Anna Dósa, Asha Kiran Maddali, András Jipa, Hajnalka Laczkó‐Dobos, Péter Lőw, Gábor Juhász   +6 more
wiley   +1 more source

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source

Compact CMOS analog readout circuit for photon counting applications

, 2013
The design, simulation results and experimental characterization of a compact analog readout circuit for photon counting applications are presented in this paper.
Ekaterina Panina, Gian-Franco Dalla Betta, Gasparini, Leonardo, Pancheri, Lucio, David Stoppa, Gian Franco Dalla Betta, Lucio Pancheri, Stoppa, David, Leonardo Gasparini   +8 more
core   +1 more source

PARK(ing) time–How park deficiency affects the biological clock in a Drosophila model of Parkinson's disease

FEBS Letters, EarlyView.
Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara, Kinga Skoczek, Elzbieta Pyza, Milena Damulewicz   +3 more
wiley   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Counting cocircuits and convex two-colourings is #P-complete

, 2008
We prove that the problem of counting the number of colourings of the vertices of a graph with at most two colours, such that the colour classes induce connected subgraphs is #P-complete.
Noble, S D
core  

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Data Structures for Colored Counting in Grids and Trees

, 2023
In this thesis, we design data structures for colored counting queries. First, we consider the colored 2D orthogonal range counting problem and present four different time-space tradeoffs. Second, we consider the batched colored path counting problem. By
Gao, Younan
core