Results 111 to 120 of about 3,030,091 (301)

Fundamental solutions for isotropic size-dependent couple stress elasticity [PDF]

open access: yes, 2013
Fundamental solutions for two- and three-dimensional linear isotropic size-dependent couple stress elasticity are derived, based upon the decomposition of displacement fields into dilatational and solenoidal components.
Dargush, Gary F., Hadjesfandiari, Ali R.
core   +1 more source

Magnetohydrodynamics and viscosity variation in couple stress squeeze film lubrication between rough flat and curved circular plates. [PDF]

open access: yesSci Rep, 2023
Byeon H   +8 more
europepmc   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

open access: yesMolecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu   +13 more
wiley   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

open access: yesMolecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim   +3 more
wiley   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

open access: yesMolecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang   +9 more
wiley   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

open access: yesMolecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

A Mathematical Theorem on the Onset of Stationary Convection in Couple-Stress Fluid

open access: yesJournal of Applied Fluid Mechanics, 2013
The thermal instability of a couple-stress fluid heated from below is investigated. Following the linearized stability theory and normal mode analysis, the paper mathematically establishes that the onset of instability at marginal state, cannot ...
Banyal Ajaib Singh
doaj  

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