Results 121 to 130 of about 102,162 (264)
Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer
Molecular Oncology, EarlyView.Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas +16 more
wiley +1 more source
Impact of partial slip and lateral walls on peristaltic transport of a couple stress fluid in a rectangular duct. [PDF]
Sci Prog, 2021 Akram S, Saleem N, Umair MY, Munawar S.
europepmc +1 more source
Spatial biology in cancer epigenetics
Molecular Oncology, EarlyView.Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley +1 more source
Effectiveness of stress inoculation training on reducing couple burnout in married women
مجله دانشگاه علوم پزشکی گرگان, 2019 Background and Objective: Couple burnout is phenomenon which affects many couples. It is the main cause of emotional divorce, and it can provide a ground for formal divorce of couples.
Fatemeh Rabiee +2 more
doaj
Analysis of newly developed fractal-fractional derivative with power law kernel for MHD couple stress fluid in channel embedded in a porous medium. [PDF]
Sci Rep, 2021 Arif M +4 more
europepmc +1 more source
Molecular Oncology, EarlyView.The cell‐autonomous roles of interferon type 1 vary based on duration and intensity. While acute, robust signaling results in cancer cell cytotoxic effects, sustained, low‐level signaling is associated with tumor‐promoting effects. This review summarizes current research of IFN‐1 in cancer and within the clinical setting, with an emphasis on female ...
Ashlyn Conant +7 more
wiley +1 more source
Molecular Oncology, EarlyView.Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche +10 more
wiley +1 more source
Comparative study of generalized couette flow of couple stress fluid using optimal homotopy asymptotic method and new iterative method. [PDF]
Sci Rep, 2021 Farooq M +5 more
europepmc +1 more source
Molecular Oncology, EarlyView.This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi +6 more
wiley +1 more source
Journal of Applied Fluid Mechanics, 2016 Exact analysis of miscible dispersion of solute with interphase mass transfer in a poorly conducting couple stress fluid flowing through a rectangular channel bounded by porous layers is considered because of its application in many practical ...
N. Rudraiah +2 more
doaj