Results 81 to 90 of about 805,646 (287)

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Influence of couple stress and magnetic fluid on the performance of step slider bearing

International Journal of Applied Mechanics and Engineering
This theoretical investigation delves into the performance of step slider bearings, considering the influence of couple stress and magnetic fluid as the lubricating medium.
Dipali K. Chauhan, JIMIT R. PATEL, G.M. Deheri   +2 more
doaj   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Elastic Stress Coupling Between Supraglacial Lakes

Journal of Geophysical Research: Earth Surface
AbstractSupraglacial lakes have been observed to drain within hours of each other, leading to the hypothesis that stress transmission following one drainage may be sufficient to induce hydro‐fracture‐driven drainages of other nearby lakes. However, available observations characterizing drainage‐induced stress perturbations have been insufficient to ...
Laura A. Stevens, Sarah B. Das, Mark D. Behn, Jeffrey J. McGuire, Ching‐Yao Lai, Ian Joughin, Stacy Larochelle, Meredith Nettles   +7 more
openaire   +2 more sources

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Coupled stress-diffusion: Case II

Journal of the Mechanics and Physics of Solids, 1993
The problem of a molecular deformation in a polymeric solid is considered using the global balance principles and micromechanical considerations. A complete set of coupled governing balance equations and constitutive laws is given. An example of the initial-boundary value problem is presented to demonstrate that the qualitative features of diffusion ...
Govindjee, Sanjay, Simo, Juan C.
openaire   +2 more sources

Effect of spin slip conditions on Couette-Poiseuille flow of couple stress fluid between parallel plates

Applied and Computational Mechanics
In the current paper, we investigate the effect of spin slip conditions for the Couette-Poiseuille flow of a couple stress fluid between two parallel plates.
Nishad S., Madasu K. P.
doaj   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

Molecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel   +10 more
wiley   +1 more source

Analysis of the Lubrication Performance of Bearing with Non-Newtonian Magnetic Fluids with Considering Stress Couple Effect

Jixie chuandong, 2017
Based on the Reynolds equation considering the stress couple and magnetic field,the numerical analysis of the non-Newtonian magnetic fluid lubricated bearing is carried out.
Chen Chao, Zhang Hong
doaj