Results 111 to 120 of about 888,971 (305)

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

A Novel Hybrid Cascaded and Stacked Coupled Inductor Boost Converter With Active Clamping Zero-Voltage Switching

IEEE Access
The application of a traditional boost converter requires a wide duty cycle for high boost voltage gain. The wide duty cycle has the problem of a high current peak due to a large input current.
Jing-Yuan Lin, Chuan-Ting Chen, Yi-Feng Lin   +2 more
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Single-stage electronic ballast using single-coupled inductor [PDF]

, 2019
This paper proposes a single-stage half-bridge electronic ballast with a high power factor using only a single coupled inductor. Compared to conventional high power factor electronic ballasts, the proposed ballast is a simpler circuit with a low cost and
Cho, YW, Kwon, BH
core   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Implementation of a Fixed Timing Coupled Inductor Soft-Switching Inverter [PDF]

, 2007
In research environments, many soft switching inverters have been conceived, simulated, designed, implemented and proven to have advantages over hard switched inverters.
Gouker, Joel Patrick
core  

Analytical and Experimental Comparison of Carrier-Based PWM Methods for the Five-Phase Coupled-Inductor Inverter [PDF]

, 2016
The five-phase coupled-inductor inverter is a newly proposed option for three-level five-phase inverter drives. This paper comprehensively analyzes the inverter including the coupled-inductor current, current stress on the dc-link capacitors, and a ...
Rahman, MF, Rahman, Faz ; https://orcid.org/, Fletcher, JE ; https://orcid.org/, Xiao, D ; https://orcid.org/, Tan, C   +4 more
core   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

A Switched-Coupled-Inductor Quasi-Z-Source Network With High Boost Capability

IEEE Access
This paper proposes a new high gain quasi-Z-source network (qZSN) using a two-winding switched-coupled-inductor (SCL). By employing a two-winding SCL within the impedance network, the proposed topology offers high boost capability at low shoot-through ...
Mehran Moslehi Bajestan, Hamed Bizhani
doaj   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source