Results 111 to 120 of about 2,413,185 (355)

A Novel Reversal Γ-Shape Coupled Inductor High-Step AC-AC Converter

open access: yesEnergies, 2018
This paper presents a novel reversal Γ-shape coupled inductor high-step AC-AC converter. This converter uses a reversal Γ-shape coupled inductor that consists of a two-winding coupled inductor for higher voltage gain.
Hongchen Liu, Xinsheng Zhang
doaj   +1 more source

Averaged dynamics of a coupled-inductor boost converter under sliding mode control using a piecewise linear complementarity model [PDF]

open access: yes, 2016
An averaged model of a coupled-inductor boost converter using the piecewise complementarity model of the converter under sliding motions is obtained. The model takes into account the idealized voltage–current characteristic of passive switches (diodes ...
Batlle Arnau, Carles   +2 more
core   +2 more sources

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang   +12 more
wiley   +1 more source

Design of a Highly Efficient Microinverter [PDF]

open access: yes, 2016
This paper proposes a grid-tied single-phase photovoltaic (PV) microinverter consisting of five-level four-switch (5L-4S) DC-AC converter fed by an isolated fly-back DC-DC converter. The microinverter utilizes a split-coil inductor to produce five levels
Crespo, Jonah   +2 more
core   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

open access: yesMolecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla   +9 more
wiley   +1 more source

Coupled Inductor Based Boost Microinverter With Dual Mode Time Sharing Operation for Renewable Energy Applications

open access: yesIEEE Access
Household power conversion stages process significant amounts of power when they add up to form a microgrid. Microinverters are considered one of the best choices to utilize the renewable energy harvested power.
Fahad M. Alhuwaishel, Nabil A. Ahmed
doaj   +1 more source

Dynamic Analysis of a Boost Topology with Ripple Cancellation and Comparison with the Conventional Boost [PDF]

open access: yes, 2009
The boost topology with ripple cancellation network allows input and output current ripple attenuation, which means the suppression of the input filter and a high reduction of the output filter. However, to achieve the ripple cancellation, the complexity
Alou Cervera, Pedro   +5 more
core   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch   +13 more
wiley   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

open access: yesMolecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute   +4 more
wiley   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

open access: yesMolecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni   +11 more
wiley   +1 more source

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