Results 101 to 110 of about 888,948 (305)

Investigation and Optimization for Planar Coupled Inductor dual-phase interleaved GaN-based Totem-Pole PFC

, 2020
This paper presents the comparison among different coupled inductors for the GaN-based critical mode (CRM) Totem-Pole PFC. The flux linkage and flux density are deduced both for the positive coupled inductor and the negative coupled inductor.
Andersen, Michael A.E., Ziwei Ouyang, Mingxiao Li, Dou, Yi, Yunfeng Liu, Li, Mingxiao, Yi Dou, Liu, Yunfeng, Ouyang, Ziwei, Michael A.E. Andersen   +9 more
core   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Coupled Inductor Based Boost Microinverter With Dual Mode Time Sharing Operation for Renewable Energy Applications

IEEE Access
Household power conversion stages process significant amounts of power when they add up to form a microgrid. Microinverters are considered one of the best choices to utilize the renewable energy harvested power.
Fahad M. Alhuwaishel, Nabil A. Ahmed
doaj   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Converter leg with coupled inductor

, 2021
Magistrsko delo obsega analizo, načrtovanje in izdelavo tranzistorske veje z dušilko s srednjim odcepom. Namen dela je bil preveriti, ali obstaja topologija tranzistorske veje, ki bi omogočala prekrivajoče prevajanje ali vsaj delno prekrivanje pri ...
Pavlovič, Marko
core  

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

An improved coupled inductor‐based quadratic step‐up DC–DC converter with a high step‐up factor and reduced voltage overshoot on the power switch

IET Power Electronics
Most coupled inductor‐based step‐up DC–DC converters encounter a significant voltage overshoot on their power switch due to the leakage inductance of the coupled inductor.
Mahnaz Izadi, Ali Mosallanejad, Alireza Lahooti Eshkevari   +2 more
doaj   +1 more source

Isolated DC-DC Converter for Bidirectional Power Flow Controlling with Soft-Switching Feature and High Step-Up/Down Voltage Conversion

Energies, 2017
In this paper, a novel isolated bidirectional DC-DC converter is proposed, which is able to accomplish high step-up/down voltage conversion. Therefore, it is suitable for hybrid electric vehicle, fuel cell vehicle, energy backup system, and grid-system ...
Chih-Lung Shen, You-Sheng Shen, Cheng-Tao Tsai   +2 more
doaj   +1 more source