Results 131 to 140 of about 5,472,167 (296)

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

First-order electroweak phase transition at finite density

Journal of High Energy Physics
We study the Electroweak phase transition with the Standard Model effective field theory at finite temperature and finite density. Utilizing the dimensional reduction approach, we construct the tree dimensional thermal effective field theory at finite ...
Renhui Qin, Ligong Bian
doaj   +1 more source

ANN-Based Inverse Modeling and Global Sensitivity Analysis of a CAR1 Damper

Applied Sciences
Friction dampers are widely used as passive energy dissipation devices in seismic protection systems; however, their response depends on numerous interacting parameters, complicating design.
Magdalini Titirla, Walid Larbi
doaj   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Properties of the $$\eta _q$$ η q leading-twist distribution amplitude and its effects to the $$B/D^+ \rightarrow \eta ^{(\prime )}\ell ^+ \nu _\ell $$ B / D + → η ( ′ ) ℓ + ν ℓ decays

European Physical Journal C: Particles and Fields
The $$\eta ^{(\prime )}$$ η ( ′ ) -mesons in the quark-flavor basis are mixtures of two mesonic states $$|\eta _{q}\rangle =|{\bar{u}} u+{\bar{d}} d\rangle /\sqrt{2}$$ | η q ⟩ = | u ¯ u + d ¯ d ⟩ / 2 and $$|\eta _{s}\rangle =|{\bar{s}} s\rangle .$$ | η s
Dan-Dan Hu, Xing-Gang Wu, Hai-Bing Fu, Tao Zhong, Zai-Hui Wu, Long Zeng   +5 more
doaj   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Radiative cooling effects on black hole hot accretion flows around the sub-Bondi radius

Astronomy & Astrophysics
Aims. It is difficult to implement numerical simulations on a region extending from the vicinity of a black hole to the Bondi radius. Most previous numerical simulations have primarily concentrated on the region close to the black hole.
Liu Mu-Qing, Yang Xiao-Hong, Bu De-Fu
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source