Results 91 to 100 of about 12,782 (273)

Super‐Refractory Status Epilepticus (SRSE) in a Patient With Compound Heterozygous OPA1 Variants: Case Report and Literature Review

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Super‐Refractory Status Epilepticus (SRSE) is a rare, life‐threatening neurological emergency with unclear etiology in many cases. Mitochondrial dysfunction, often due to disease‐causing genetic variants, is increasingly recognized as a cause, with each gene producing distinct pathophysiological mechanisms.
Pouria Mohammadi, Lara Basovic, Christopher Michael McGraw   +2 more
wiley   +1 more source

Innate Immune Reprogramming Mediated by Endogenous Retroelement Dysregulation Drives Multiple Sclerosis Progression

Annals of Clinical and Translational Neurology, EarlyView.
Epigenetic reprogramming in hematopoietic stem and progenitor cells (HSPCs) and downstream myeloid cells, mediated by H3.3 downregulation and endogenous retroelement (ERE) overexpression, contributes to the progression of multiple sclerosis (MS). ABSTRACT Background Skewed myelopoiesis in the bone marrow has been identified as a key driver of multiple ...
Li‐Mei Xiao, Qiu‐Ping Zhao, Run‐Yun Li, Wei Chen, Huan‐Huan Song, Wan‐Jin Chen, Ying Fu   +6 more
wiley   +1 more source

SOME COUPLED COINCIDENCE AND COMMON COUPLED FIXED POINT THEOREMS IN COMPLEX-VALUED METRIC SPACES [PDF]

, 2015
The aim of this paper is to obtain a coupled coincidence point theorem and a common coupled fixed point theorem of contractive type mappings involving rational expressions in the frame work of a complex-valued metric spaces.
Khan, M S, Jhade, Pankaj Kumar
core  

ALDOA Promotes Glycolysis and NLRP3/GSDMD Pyroptosis to Accelerate ALS Progression

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is characterized by progressive motor neuron degeneration. Glycolytic dysregulation is implicated in disease progression, yet the underlying mechanisms remain unclear. This study investigates how Aldolase A (ALDOA) drives ALS progression through glycolysis‐mediated motor neuron pyroptosis.
Kaixin Yan, Yan Jiang, Yuxuan Yong, Tianshuo Zhang, Niannian Zhang, Qianqian Zeng, Xue Gong, Li Meng, Fangfang Bi, Yongmin Liu   +9 more
wiley   +1 more source

The Existence of Solutions for Four-Point Coupled Boundary Value Problems of Fractional Differential Equations at Resonance

Abstract and Applied Analysis, 2014
A four-point coupled boundary value problem of fractional differential equations is studied. Based on Mawhin’s coincidence degree theory, some existence theorems are obtained in the case of resonance.
Yumei Zou, Lishan Liu, Yujun Cui
doaj   +1 more source

Paramagnetic Rim Lesions and Choroid Plexus Volume at Diagnosis Are Associated With Cognitive Progression Independent of Relapse and MRI Activity in Early Relapsing–Remitting Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Paramagnetic rim lesions (PRLs) and choroid plexus (CP) enlargement reflect smoldering inflammation in multiple sclerosis. Their role in cognitive progression remains unexplored. Eighty‐seven early relapsing–remitting MS patients were enrolled at diagnosis and followed longitudinally.
Stefano Ziccardi, Damiano Marastoni, Agnese Tamanti, Pietro Biasi, Valentina Visani, Annalisa Colombi, Tom A. Fuchs, Monica Sicchieri, Chiara Eccher, Francesco Guarnaccia, Milena Calderone, Valentina Camera, Francesca Benedetta Pizzini, Roberta Magliozzi, Marco Castellaro, Massimiliano Calabrese   +15 more
wiley   +1 more source

ON COINCIDENCE POINT THEOREM FOR NEW CONTRACTIVE CONDITION WITH APPLICATION [PDF]

, 2017
We establish coincidence point theorem for g-non-decreasing mappings satisfying new contractive condition on partially ordered metric spaces. With the help of obtain result, we show the formation of the coupled coincidence point theorem for generalized ...
Amrish Handa, Handa, Amrish, Deshpande, Bhavana, Bhavana Deshpande   +3 more
core   +1 more source

Evaluation of a Novel Electric Health Record Sidecar Application to Display Rheumatoid Arthritis Clinical Outcomes During Clinic Visits: Results of a Stepped‐Wedge Cluster Randomized Pragmatic Trial

Arthritis Care &Research, EarlyView.
Objective We developed a novel electronic health record sidecar application to visualize key rheumatoid arthritis (RA) outcomes, including disease activity, physical function, and pain, via a patient‐facing graphical interface designed for use during outpatient visits (“RA PRO dashboard”).
Gabriela Schmajuk, Jing Li, Cathy Nasrallah, Cherish Wilson, Alicia Hamblin, Christine Hariz, Cammie Young, Stephen Shiboski, Emma Kersey, Mary Nakamura, Judith F. Ashouri, Mehrdad Matloubian, Andrew J. Gross, Jennifer Barton, Beth Berrean, Jonathan Prugh, Jinoos Yazdany   +16 more
wiley   +1 more source

Coupled Coincidence and Coupled Common Fixed Point Results of Mixed Monotone Mappings in the setting of Partially Ordered Metric Spaces [PDF]

, 2020
The purpose of this research is to establish the existence and uniqueness of coupled coincidence and coupled common fixed point results of mixed monotone mappings in the setting of partially ordered metric spaces.
Nigus Baye
core  

Promotion of Coupled Fixed Point Theorem in Partially Ordered Metric Spaces

四川大学学报. 自然科学版, 2017
In this paper, we first establish new coupled coincidence and coupled common fixed point theorems in partially ordered metric spaces, and then apply the new coupled common fixed point theorem to prove the existence and uniqueness of solutions to ...
MA Jin, YANG He
doaj